Bi-Est E2/E3 (80/20) cream is generally well-tolerated, but some users may experience mild skin irritation, breast tenderness, or occasional headaches or nausea as their body adjusts. Light spotting, bloating, or mood changes can also occur during the first few weeks of use. These symptoms often diminish with continued, consistent application. If side effects persist or become bothersome, adjusting the dosage, application site, or frequency—and consulting with a healthcare provider—can typically help resolve the issue.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
