Estradiol patches are generally well-tolerated, but the most common complaints are mild skin irritation or redness where the patch sits, along with breast tenderness and occasional headaches or nausea. Some women also notice light spotting, bloating, or mood swings when their body is adjusting to the hormone, and these effects often fade after the first few weeks of consistent use. If irritation persists or symptoms feel bothersome, switching application sites or dosage—and checking in with a clinician—usually resolves the issue.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
