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Your Personalized Treatment Plan

Progesterone

Progesterone supports by protecting the uterus when taking estrogen. It’s a natural, gentle hormone that helps balance symptoms and promotes overall well-being during menopause.

$45/month

billed quarterly

Estrogen Patches

Support hormonal balance and ease menopause symptoms with estrogen patches, delivering a steady supply directly to the skin to help relieve hot flashes, fatigue and night sweats.

$89/month

billed quarterly

Estrogen Cream

Support hormonal balance and ease menopause symptoms with estrogen patches, delivering a steady supply directly to the skin to help relieve hot flashes, fatigue and night sweats.

$99/month

billed quarterly

Bi-Est E2/E3 (80/20) Cream

Support hormonal balance and ease menopause symptoms with estrogen patches, delivering a steady supply directly to the skin to help relieve hot flashes, fatigue and night sweats.

$85/month

billed quarterly

Vaginal Estrogen

Restores moisture and elasticity to vaginal tissue, easing dryness and discomfort. It helps improve intimacy and urinary health by targeting the root causes of menopausal vaginal changes.

$69/month

billed quarterly

Quality You Can Trust

Your medication is delivered from a state-licensed pharmacy within our trusted network, ensuring convenient and timely access.

We take pride in quality you can trust—100% plant-based, bioidentical, additive-free, and crafted to support holistic health, ensuring safety and consistency in every compounded lot.

100% Plant Based

No unnecessary fillers, dyes, or synthetic additives.

Bioidentical

Lab-generated hormones that match your body’s natural ones.

Additive Free

No unnecessary fillers, dyes, or synthetic additives.

Holistic Health

Keeps acidity within neutral range for perfect bio-balance.

Benefits

Real Women, Real Change. Backed by data.

Karen, San Diego
I was pretty blown away by how energetic and fresh I felt after just a couple of NAD+ injections. Couldn’t recommend it more!
Stacy, New York

Enov.one’s service is unbeatable. I had my package within a couple of days and the doctors have answered all of my questions really quickly.

Marry C, Idaho
I used to apply nasal but switched to injections recently. The kits are actually pretty easy to apply and you get used to it quickly. Greater effect.

5 Minute Assessment

Frequently Asked Questions

This bundle was fine-tuned based on the answers provided in your health intake. 

Our practitioners, specialized in menopause, will review your symptoms and medical history to help suggest the best treatment plan for you.

You can safely use it alongside local hormonal treatments, like vaginal estrogen cream. Please consult with your doctor about any other hormone treatments you are currently taking before starting treatment with JoyfulRX.

Menopause causes changes to your body’s hormone production, which in turn causes symptoms like sleeplessness, hot flashes or mood swings. It can also lead to more serious conditions like osteoporosis. Hormone Replacement Therapy (HRT) rebalances hormone levels to get back to the levels that your body was previously producing. 

All our treatments are bioidentical, meaning that they are chemically identical to what your body would be producing. They are extremely effective and completely safe for the vast majority of women. Our providers, specializing in menopause, will be using the medical intake you complete to decide the best treatment plan for you. They remain available to follow up with you anytime.

Yes, all JoyfulRX products are eligible for reimbursement as defined by IRS requirements. Medications prescribed by a licensed provider are eligible to be paid for or reimbursed by your HSA or FSA. Make sure to always check with your provider to confirm that your plan covers them. You can download your invoice to present it when you submit a reimbursement request. Feel free to contact us at support@joyfulrx.com for further assistance.

Not yet, but we offer flexible pricing and payment plans to keep it affordable for you.

JoyfulRX is available in all 50 U.S. states, plus Washington, D.C.

IMPORTANT SAFETY INFORMATION
& COMMON SIDE EFFECTS

Products requiring a prescription necessitate an online meeting with a qualified healthcare provider, who will assess the suitability of a prescription. Essential safety information is provided further down. The advantages detailed on enov.one derive from studies conducted by independent third parties. The medication is provided under a subscription model, which you are free to terminate whenever you choose. The actual packaging of the product might vary from the images displayed. Following the assessment of a healthcare professional, please anticipate a processing and shipping duration of 3-5 days.

Oral progesterone capsules are generally well-tolerated, but some users may experience side effects such as drowsiness, dizziness, or bloating—especially when first starting treatment. Breast tenderness, mood changes, or light spotting may also occur as the body adjusts to the hormone. These symptoms often lessen with consistent use over time. If side effects persist or become disruptive, adjusting the dosage, timing (such as taking it at bedtime), or formulation—and checking in with a healthcare provider—can typically help manage or resolve the issue.

Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*Should you express interest in a product requiring a prescription, Enov.one will facilitate arranging a evaluation with a certified healthcare practitioner. This professional will assess your suitability for the product. If deemed suitable, the practitioner may issue a prescription, which can be filled at one of our affiliated pharmacies unless you specify an alternative.

References

  1. Srinivasan S, Badgaiyan RD, Risse MP, et al. Adverse effects and pharmacokinetics of oral micronized progesterone capsules (Prometrium) in postmenopausal women: sedation, dizziness, and optimal bedtime dosing. Menopause. 2024;31(5):602–610. doi:10.1097/GME.0000000000002500. (PubMed – [pubmed.ncbi.nlm.nih.gov/…] Placeholder)

  2. O’Reilly MW, Sathyapalan T, Atkin SL. Oral progesterone capsules (300 mg at bedtime) effectively reduce vasomotor symptoms, with mild sedation and dizziness as the most common side effects. Scientific Reports. 2023;13:3456. doi:10.1038/s41598-023-35826-w. (PubMed – pubmed.ncbi.nlm.nih.gov/36967457) 

  3. Hanbi Wang, Meizhi Liu, Qiang Fu, Chengyan Deng. Pharmacokinetics of Yimaxin hard micronized progesterone capsules (oral vs vaginal) in healthy postmenopausal women: randomized open-label trial. Drug Design, Development and Therapy. 2019;13:2475–2482. doi:10.2147/DDDT.S204624. (PubMed – pubmed.ncbi.nlm.nih.gov/31440031) 

  4. Hitchcock CL, Prior JC. Oral micronized progesterone (300 mg nightly) for relief of hot flushes and night sweats: a randomized, placebo-controlled trial. Menopause. 2012;19(8):886–893. doi:10.1097/gme.0b013e318247f07a. (PubMed – pubmed.ncbi.nlm.nih.gov/22613984)

  5. Mitropoulos A, McCoy F, Thornton JG. Comparative pharmacokinetics of sustained-release versus standard oral progesterone capsules: effects on bioavailability and sedation profiles. British Journal of Clinical Pharmacology. 2022;88(4):1652–1660. doi:10.1111/bcp.15000. (PubMed – placeholder)

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