Instant relief for menopause symptoms
Personalized hormone therapy to ease
- Hot flashes
- Low energy
- Hair loss
- Mood swings
- Low libido
- Adult acne
feel like you again in just 2 weeks* for $140/month
Precision Health Solution
Bioidentical Hormone Therapy
Testing 1 Million+ Biomarkers
Leading US Based Physicians
Personalized Progress Tracking
24/7 Online Support
“Biomarkers hold the key to truly personalized healthcare—understanding them transforms how we approach wellness and aging”
Backed by Dr. Mike Snyder, a world leader in precision medicine and cell genomics from Stanford University.
Hormone changes are real,
and we’re here to listen.
Struggling with these symptoms?
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Finally, care that
adapts to you.
Own your health with an HRT plan that evolves with your body’s needs.
Dashboard
Test Results
Physician Support
Personalized Protocol
Dashboard
An easy-to-use dashboard that keeps you on track. See how your medications are working, check upcoming lab tests, and know when prescriptions are ready.
Test Results
Get a clear breakdown of your biometrics and track progress over time. As your body changes, regular testing keeps your treatment plan up to date.
Physician Support
Get help anytime from our US-based team of doctors. Whether you have questions or need a change in your plan. we’re always here for you.
Personalized Protocol
Your medications, supplements and plan—all in one place. View past prescriptions, track updates, and stay organized as your needs evolve.
‘’After years of struggling with energy and hormone issues, discovering Joyful was a breakthrough. Their approach—looking beyond momentary biomarkers—validates what so many of us feel: something’s off. For the first time, I’m confident I have a team that truly has my best interests in mind.’’
-Shiloh Walton 
‘’The HRT program has been a game-changer for me. I’ve noticed real changes in my energy levels and mood. It’s been amazing to have a team that really listens and adjusts my treatment as needed!.’’
-Sarah T. 
‘’I was hesitant at first, but after just a few months on the program, I feel like myself again. The personalized approach makes all the difference, and I love knowing I’m getting the right treatment for my body.’’
-Emily R. 
‘’This program helped me regain balance and feel more like me. The support from my care team has been incredible, and I love the way they continuously monitor and adjust my treatment.’’
-Laura B. 
‘’I’ve been on the HRT program for 6 months now, and the changes have been amazing! My energy is up, my sleep is better, and I finally feel like I’m taking control of my health.’’
-Jessica K. 
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Start feeling better after just 2 weeks.
A year of care built and evolving just for you.
You’re not alone in menopause. Here’s how our support and medical protocols
evolve over a whole year to keep you feeling your best.
What you deserved to know about HRT all along
Reduction in hot flashes and night sweats within weeks of starting HRT.
Reduction in hot flashes and night sweats within weeks of starting HRT.
Experience depression during menopause and find relief with HRT.
Experience depression during menopause and find relief with HRT.
Reported improved hair and dental health after six months of HRT.
Reported improved hair and dental health after six months of HRT.
Reported improvement in memory and cognitive clarity within 6 months on HRT.
Reported improvement in memory and cognitive clarity within 6 months on HRT.
Transparent, simple pricing for extensive care
Joyful HRT Program
Annual Plan
$3,000 $2,000
Save 33% once you sign up for the whole year
Billed annually
Billed annually
Monthly Plan
$250 $140
EXCLUSIVE OFFER: Get 44% off your first month
Billed $250 monthly afterward
Billed $250 monthly afterward
No hidden fees, no insurance required
- Cancel anytime
- 100% money back guarantee
- Full refund if you're not qualified
- Free shipping
- 24/7 access to doctor support
How does testing 1 million+ biomarkers help me?
Dr. Mike Snyder, a world leader in precision medicine from Stanford Medicine, shows how advanced biomarker testing leads to better, more personalized care.
Unlike most treatments that test just one type of estrogen, Joyful measures multiple forms to understand its full impact on your body.
Inspired by Dr. Snyder’s research, Joyful designs treatments tailored to your hormonal needs—delivering precise, effective care.
Significance of Biomarker Testing in Precision Medicine: Why biology is catalyzing breakthroughs in women’s health. Snyder’s biological aging patterns study: ‘Ageotypes’ provide window into how individuals age, Stanford study reports. Novel blood analysis method to measure thousand of molecules from a single drop of blood: ‘Theranos that works’: Stanford researchers say they’ve measured thousands of molecules from a single drop of blood.
Unlocking the science behind
feeling like yourself again
Going deeper than symptoms
Most test stop at surface-level symptoms. Endophenotyping digs deeper and gives us insight to:
- Your genetics and how they affect you
- How hormones interact in your body
- Specific markers that point to imbalances
- How your cells are working
- Brain and nerve responses
- Metabolism and energy use
- Gut health and environment
- How well your organs are functioning
Testing that finds answers
We find the root causes behind your symptoms to guide better, more precise care:
- Genetic analysis
- Hormone testing
- Metabolism checks
- Brain and nerve assessments
- Gut and environmental health
Care that’s built for you
This is the new way forward. Endophenotyping replaces one-size-fits-all care with solutions made for you. It’s healthcare that listens, understands and works for your body.
A $39,250 treatment for only $250 per month
We’ve made advanced healthcare simple and affordable. By using in-depth lab tests and cutting-edge technology, we lower costs without losing quality. Better care, made easy and accessible for women.
Frequently asked
questions
Hormone replacement therapy (HRT) helps balance estrogen, progesterone and testosterone levels that drop with age. It relieves menopause symptoms and lowers the risk of long-term health issues caused by hormone changes.
We’ve made healthcare simple and efficient. By using advanced lab testing and cutting-edge technology, we cut out expensive in-person visits and extra costs. This allows us to provide top-quality care at a price that works for more women.
Your safety comes first. Our doctors carefully review your medical history to make sure HRT is right for you. For most women, HRT is safe and highly effective. Our team will explain any risks and benefits so you can feel confident.
Everyone’s different, but many women see improvements in hot flashes, night sweats, and sleep within a few weeks. Weight changes or muscle gain can take up to three months, with 80% of women feeling full relief by then. Your doctor will adjust your plan as needed.
No worries. Our program works with your current supplements. Our team will check to make sure everything is safe and works together so you can stick to your routine.
Our entire team—including doctors and customer care—is based in the US. You’ll have 24/7 support from people who understand your needs and are here to help anytime.
Our program offers medications like estradiol, estriol, progesterone and testosterone (if recommended by your care team). They come in pills, creams or patches based on what works best for you. You’ll also get a custom supplement plan based on your needs, with options to buy trusted brands or a custom blend for an extra fee.
Not yet, but we offer flexible pricing and payment plans to keep it affordable for you.
Menopause relief that works—because it starts with a
doctor who believes in you.
No two bodies are the same. We create a personalized plan based on your lab tests and symptoms, adapting as your needs change. Start today—get results or your money back.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Enov.one is not intended to diagnose or treat any mental or physical health condition. The use of Enov.one is not a substitute for care by a physician or other health care provider, and any report or test results produced by Enov.one is not medical advice. Enov.one users should direct any questions regarding the diagnoses, care, or treatment of a health condition to that user’s physician or health care provider. All Enov.one tests are intended solely for wellness purposes.
