Hydroquinone/Tretinoin
Lightening Cream
Backed by over 10,000 Customers Reveal a brighter, even complexion with this cream, combining Tretinoin, Hydroquinone, and Fluocinolone. This powerful formula targets dark spots, melasma, and hyperpigmentation to smooth skin tone, restore radiance, and leave you glowing with confidence.
Start with a 1-month Supply | 30 mL
- Lab tested for quality to promote patient safety
- Pay with FSA/HSA
- Compounded in the USA
- 5 minute Assessment
$66/month • Billed Quarterly
Yes. Because this formula contains active ingredients like Tretinoin, Hydroquinone, and Fluocinolone, it requires a valid prescription. Just complete a 5-minute online intake and one of our licensed providers will determine if it’s right for your skin.
Most people start noticing visible improvement in skin tone and dark spots as early as 4 weeks into consistent use. Individual results may vary depending on your skin type and condition.
Some users may experience mild redness, dryness, or flaking as the skin adjusts. It’s important to use sunscreen daily and follow your provider’s instructions carefully. This product is not recommended during pregnancy or breastfeeding.
Active Ingredients
Always Quality-tested
Your medication is securely delivered from a state-licensed pharmacy within our trusted network, ensuring timely and convenient access.
To maintain the highest quality standards, each pharmacy partners with FDA and DEA-registered labs for third-party testing, verifying the safety and consistency of every compounded lot prescribed to our patients.
Sterility Test
Ensures a product clean of impurities or other infectious agents.
Endotoxicity Test
Avoiding bacterial toxins that could cause adverse reactions.
Potency Test
Secures efficacy, keeping the active ingredient in range.
Ph Test
Keeps acidity within neutral range for perfect bio-balance.
Real users. Real results.
“At 46, I wasn’t expecting much from a face cream—but within weeks, my skin looked brighter, firmer, and more alive. It’s like I finally found something that actually works with my skin, not against it.”
Courtney S. 46
Santa Barbra, CA
Take Assessment
Take our quick 5 minute assessment and determine your eligibility.
Connect & Consult
Connect online with one of our board-certified doctors for a consultation.
Start Your Journey
Your medication will be shipped to your door, with safe, fast, and free delivery.
Real Women, Real Change. Backed by data.
Rose, San Clemente
I was able to get quick results compared to local HRT doctors. I have loved being part of the program. Brain fog, night sweats, inability to focus- all improved.
- Verified Joyful Rx Client
Victorie, Temecula
I’ve noticed increased focus and memory, and can get through my to-do list again. Helps me run my family and have them function better!
- Verified Joyful Rx Client
Sonia, Santa Barbara
I feel more energy and am back on track with my workout routine. I had kinda lost some of that motivation and so I’m feeling great to be back!
- Verified Joyful Rx Client
Frequently Asked Questions
Begin by taking our short online assessment. Based on your responses, we’ll determine if you’re eligible for our services and connect you with one of our board-certified doctors for validation, all from the comfort of your home.
You can safely use it alongside local hormonal treatments, like vaginal estrogen cream. Please consult with your doctor about any other hormone treatments you are currently taking before starting treatment with JoyfulRX.
Menopause causes changes to your body’s hormone production, which in turn causes symptoms like sleeplessness, hot flashes or mood swings. It can also lead to more serious conditions like osteoporosis. Hormone Replacement Therapy (HRT) rebalances hormone levels to get back to the levels that your body was previously producing.
All our treatments are bioidentical, meaning that they are chemically identical to what your body would be producing. They are extremely effective and completely safe for the vast majority of women. Our providers, specializing in menopause, will be using the medical intake you complete to decide the best treatment plan for you. They remain available to follow up with you anytime.
Menopause causes changes to your body’s hormone production, which in turn causes symptoms like sleeplessness, hot flashes or mood swings. It can also lead to more serious conditions like osteoporosis. Hormone Replacement Therapy (HRT) rebalances hormone levels to get back to the levels that your body was previously producing.
All our treatments are bioidentical, meaning that they are chemically identical to what your body would be producing. They are extremely effective and completely safe for the vast majority of women. Our providers, specializing in menopause, will be using the medical intake you complete to decide the best treatment plan for you. They remain available to follow up with you anytime.
Menopause causes changes to your body’s hormone production, which in turn causes symptoms like sleeplessness, hot flashes or mood swings. It can also lead to more serious conditions like osteoporosis. Hormone Replacement Therapy (HRT) rebalances hormone levels to get back to the levels that your body was previously producing.
All our treatments are bioidentical, meaning that they are chemically identical to what your body would be producing. They are extremely effective and completely safe for the vast majority of women. Our providers, specializing in menopause, will be using the medical intake you complete to decide the best treatment plan for you. They remain available to follow up with you anytime.
Yes, all JoyfulRX products are eligible for reimbursement as defined by IRS requirements. Medications prescribed by a licensed provider are eligible to be paid for or reimbursed by your HSA or FSA. Make sure to always check with your provider to confirm that your plan covers them. You can download your invoice to present it when you submit a reimbursement request. Feel free to contact us at support@enov.one for further assistance.
Not yet, but we offer flexible pricing and payment plans to keep it affordable for you.
JoyfulRX is available in all 50 U.S. states, plus Washington, D.C.
JoyfulRX is available in all 50 U.S. states, plus Washington, D.C.
JoyfulRX is available in all 50 U.S. states, plus Washington, D.C.
Backed by over 10,000 Users