Sorry to break it to you, but we’re still a long way off finding the answer to eternal youth and endless energy. But don’t worry! While we’re searching for the fountain of youth, there are some things we can do to get halfway there.
You’re reading this blog, so you’ve probably heard of NAD+. You might not know too much about it, just that it can give you more energy, boost longevity, and basically have you glowing like the best version of yourself.
Sounds good, right?
Of course it does! And if you check out photos of people before and after having NAD+, you’ll probably instantly ask where you can sign up.
But, like anything in life, especially anything you put in your body, it’s important to learn more about it first. For instance, what is the optimum NAD dosage per day? What even is it in the first place? Don’t worry, we’re going to break it down and give it to you straight. At Enovone, you living your best life is high up on our agenda; in fact, it’s our number one concern.
So, if you’re ready to learn more about the wonder-coenzyme, stick around and let’s explore together.
Table of Contents
TL;DR
- NAD+ is a crucial coenzyme that helps power up your cells, especially for energy production and healthy aging.
- You can boost NAD+ levels through methods like IV drips, self-injections, or nasal sprays — each with different absorption rates.
- There’s no one-size-fits-all dose — factors like age, health goals, and lifestyle play into finding your ideal daily amount.
- Cycling your NAD+ intake (like a few days on, a few off) or pulsed dosing may help prevent tolerance and keep your system responsive.
- Too much of a good thing can backfire — watch for side effects like fatigue, nausea, or mood shifts if you go overboard.
- Research is evolving fast, and future dosing might be even more personalized, data-driven, and effective. Stay tuned!
Understanding NAD+ Fundamentals
Okay, let’s break it down. NAD stands for Nicotinamide Adenine Dinucleotide, and it’s a co-enzyme. This is something that’s already in your body, but as you age (and sometimes due to other reasons), your natural stores reduce.
NAD+ has many functions within your body, especially in metabolism, cellular repair, and DNA repair. If you’re low on NAD+, you might find yourself feeling tired, have trouble sleeping, and notice faster signs of aging. You might also find yourself wondering where you left your keys more often, a key sign of a foggy brain. Low NAD can also affect your mood and, if you’re an athlete, can reduce your performance level.
The Biochemistry of NAD+
Don’t worry; this isn’t an in depth science lesson, but it’s a good idea to learn more about NAD+ to help you make a strong, personal decision.
Basically, NAD+ is an electron carrier, and it has a very important role to play in your metabolism. One of its most important jobs is to convert nutrients into cellular energy, which then gives you more energy overall. When NAD+ is lacking, you might feel like you just can’t be bothered with anything; getting out of bed might feel like a chore.
Does this sound familiar?
Cellular Energy Production
Let’s dig into energy production a little deeper. We know that NAD+ transports electrons, and it does this throughout your mitochondria. As a side note, mitochondria make energy from your cells. When all of this is working as it should, something called ATP is made. This stands for adenosine triphosphate, and it’s another part of the process you need to help you feel like you could run a marathon. Or just go about your business without yawning.
We’ve mentioned that as you get older, your NAD+ levels naturally drop, and this starts around middle age. By this point, you’ll have 50% less than you had before. The effects? You’ll have far less energy, and running that marathon (or just walking into town) feels like an uphill battle.
Of course, there is an answer to this – all is not lost. Supplementing with NAD+ injections or nasal spray can give you back what you’ve lost. But don’t worry, we’re going to talk about that in more detail later.
Sirtuin Activation
Let’s introduce another term – sirtuin.
Sirtuins are proteins that regulate your cellular health. They give you important stress resistance and contribute toward longevity. Now, when your NAD+ levels naturally fall, so does sirtuin activity. This means that your cells can’t function and before, and they’re not great at resisting stress. Again – hello tiredness, brain fog, and difficulty sleeping.
Yet, one of the major NAD benefits is a boost to sirtuin activity, improving DNA repair, metabolic health, and cutting back on cellular aging.
NAD+ Depletion Factors
We’ve mentioned that age is the biggest factor in dwindling NAD+ levels, but there are some other things to bear in mind too. If you suffer from chronic inflammation, you have a poor diet, you take certain medications, or you have a high level of oxidative stress, your NAD+ levels may drop.
So, it may be that you’re nowhere near middle age yet, but you’re noticing the tell-tale signs of low NAD.
NAD+ Delivery Methods and Bioavailability
NAD benefits are far-reaching, boosting quality of life over time.
Okay, we’ve talked about what NAD+ is and its benefits, now it’s time to start delving into NAD dosage per day. But before we get to that, how can you actually administer NAD?
There are several options, including IV supplementation, injection, and nasal sprays. The downside of IV infusion is the time it takes, and it can be quite an expensive option. That’s why we offer affordable NAD+ injections you can use at home, in your own time. For those who don’t particularly like needles, our NAD+ nasal spray is a quick and effective way to get all the benefits.
But of course it’s a good idea to explore all your options fully before landing on a decision. It is possible to take oral supplements, but these don’t absorb and are injected or sprayed versions. When making a choice, think about your preferences, cost, and how comfortable you are with administering the product.
If you’re still undecided, check out the table below for some extra information to help you make up your mind.
Delivery Method | Typical Dosage Range | Bioavailability | Administration Frequency |
Oral Precursors | 250-1000mg daily | 10-60% depending on precursor | Daily |
Sublingual NAD+ | 100-200mg daily | 60-80% | Daily or twice daily |
Subcutaneous Injection | 50-100mg | 90-95% | Daily to weekly |
Intramuscular Injection | 100-250mg | 95-98% | Weekly to monthly |
IV Therapy | 500-1000mg | 100% | Weekly to monthly |
Transdermal | 10-50mg per application | 5-30% | Twice daily |
Intranasal | 10-20mg per application | 30-60% | 1-2 times daily |
Injectable NAD+ Protocols
Let’s talk about starting on NAD+ injections. These are our leading products for convenience. They deliver the NAD directly into your bloodstream, avoiding any breakdown in the stomach, and it’s fast.
Of course, it does require you injecting it yourself, which may be nerve wracking a first. However, we offer plenty of help and support, and once you’ve done it a few times, you’ll wonder why you were worried in the first place.
Subcutaneous vs. Intramuscular Administration
There are two ways to give an injection – subcutaneously or intramuscularly. Subcutaneous means into the fatty tissue just under the skin, while intramuscular means into the muscle. Our NAD+ injections should be given subcutaneously, allowing the product to quickly absorb into your bloodstream and get to work.
We recommend starting with a dose of 0.1ml for general health. If you need to, you can slowly increase the NAD injection dosage per day to a maximum of 0.5ml. This is the equivalent of 50mg of NAD+. This can be taken up to three times per week.
To clarify, every 0.1ml increment on the syringe equals 10 units. So, it delivers 10mg of
Each increment of 0.1ml on the insulin syringe, corresponding to 10 units, delivers 10mg of NAD+.
Of course, it sounds daunting at first, but don’t worry. We’re on hand to help you every step of the way with any questions you have. You’re certainly not alone on this journey!
NAD+ IV Therapy Considerations
Another injection-based option is IV NAD+ therapy. This has its pros and cons, so it’s important to weigh them up carefully if you’re considering attending a clinic for treatment.
In this case, the NAD is given slowly, often over the course of a few hours, under medical supervision. For sure, IV infusion does give maximum effects, but it’s a lot more expensive and there’s the time factor to consider too.
While there is a small chance of side effects no matter what administration method you choose, the rate of infusion can lead to a slightly higher chance. In this case, you may notice flushing and nausea, which although normal, can be uncomfortable.
NAD dosage per day depends on administration method, including IV versus injection NAD.
Topical and Intranasal Applications
If injections don’t sound like your idea of fun (we’re all unique) then there are some alternative delivery methods to explore. These include the nasal sprays we mentioned earlier, as well as topical creams, like our NAD+ face cream.
These are quite convenient options, especially if you’re traveling or you just don’t like injections. However, they usually deliver less NAD+ and absorption can be slower. Because of that, NAD dosage per day needs to be measured carefully to get the best effects.
Transdermal NAD+ Absorption Rates
NAD skincare products usually contain 1.5% concentration, which equates to 10-50mg for every application. The recommendation is to apply the product twice daily.
However, there are some variables that can affect how well the product absorbs and how quickly it gets to work. This includes your skin thickness, how hydrated you are for absorption, and the actual formula for the product.
Intranasal Delivery Pharmacokinetics
You might be wondering how NAD+ nasal sprays work. It’s interesting to learn, and it shows just how many alternative administration routes there really are.
The inside surface of the nose, called the mucosa, is rich in blood supply, packed with many tiny blood vessels. This is ideal for fast absorption into the bloodstream.
Here, the NAD dosage per day is one spray in each nostril, twice per day. While nasal sprays give better absorption when oral supplements, they lag slightly behind injections. Despite that, it’s a good middle ground and certainly adds the convenience factor.
Personalized NAD+ Dosing Frameworks
While we can give you plenty of advice on Nicotinamide Adénine Dinucléotide and general dosage, we’re all unique in our own ways. This means several things can affect the actual dosage you need. The good news is that you certainly don’t need to worry about it; our board-registered doctors will give you all the personalized information you need.
Yet, before that, it’s good to know about the different factors that can affect NAD dosage per day. So, what does it include? First, age, then your general health status, any genetic factors, and your general goals. There isn’t a one-size-fits-all approach here, so we’ll take into account everything in your health history and what you want to achieve. That way, you’ll be much happier with the ongoing result.
Age-Stratified Dosing Recommendations
You already know that NAD levels drop as the years roll by, but dosage can also be tailored to your specific age at this moment in time. That’s because your NAD requirements change at different times of your life, and if you want to maximize their impact, a tailored approach works best.
Midlife Optimization (40-60 years)
The most significant drop in NAD+ levels happens between age 40-60, what most people would call midlife. The good news is that we can tailor your dosage to give you the most NAD benefits right now. From there, it’s about careful monitoring of any energy changes, cognitive function, and sleep quality. That will give us plenty of information to decide whether your dosage needs to increase, decrease, or stay the same.
Remember, everyone is different, and that means your body may respond differently to your friend’s or your neighbor’s.
Senior Support Protocols (60+ years)
If you’re over 60 years of age, you may notice benefits from a higher maintenance dose, but careful monitoring here is key. That’s because there may be effects on your metabolism beyond those you really want, or medication interactions.
In some cases, dividing the dose between the day can help with tolerance and effectiveness, but again, we’re all different! That means careful monitoring and advice from your healthcare professional.
Preventative Approaches (Under 40)
We mentioned that NAD levels naturally drop around middle age, but that doesn’t mean you can’t get ahead of the curve, particularly before the age of 40. In this age group, you’re likely to need a much lower dose, and it’s about preserving your NAD+ levels rather than restoring them. In this case, cycling protocols can be useful. This means you’ll usually have five days on and then two days off.
Condition-Specific Therapeutic Dosing
Alongside age, there are some health conditions that may cause NAD to be on the lower side. Let’s look at how specific health concerns can benefit from optimized NAD dosage per day.
Neurocognitive Support
Certain conditions that affect brain health may benefit from higher doses of NAD+, focusing on absorbing through the blood-brain barrier. Administering the treatment in the mornings usually results in better outcomes, but a few months of treatment are usually needed before any major improvements appear.
Metabolic Dysfunction Protocols
Insulin resistance and metabolism syndrome may benefit from NAD+ supplementation. This is because low NAD+ levels can worsen insulin resistance, which creates a vicious cycle of further depleting NAD+. Breaking the cycle is possible, and divided dose strategies, with morning and afternoon administration can be useful.
Adverse Reactions and Dosage Limitations
Like any health-related product, NAD+ may cause some side effects and adverse reactions. In most cases, this is very mild and generally disappears within a short amount of time, but it’s vital to monitor your response carefully. Of course, this approach also helps you find the best dosage for your specific needs, in consultation with your healthcare professional.
Recognizing Overdosage Indicators
NAD benefits are wide-ranging but it’s important to understand the potential side-effects.
Your first question may be how you can spot a potential overdose. Thankfully, there are certain signs you can spot that could be an indicator that your dose is too high. These signs tend to show themselves before any serious adverse effects, so it’s critical to pay attention and act to avoid a serious outcome.
In most cases, early warning signs resolve quickly once the dosage is tweaked or discontinued temporarily. Yet, remember what we’ve already said – everyone is different, and that means sensitivity varies drastically across the board. You know your body the best and at Enovone, we’re committed to helping you find the ideal dosage for your specific needs.
Methylation Overload Symptoms
One thing to look out for is methylation overload. This can happen because NAD+ metabolism interacts with methylation pathways, potentially throwing your levels out of whack.
So, how can you spot this? Typically, anxiety, racing thoughts, insomnia, and headaches are common signs. It often means that dosage needs to be reduced, bringing methylation levels back to normal.
Special Population Considerations
In-keeping with our ‘everyone is unique’ theme, there are also certain demographic groups that may need to modify their NAD injection dosage per day. This is due to unique factors that alter how they process and utilize NAD, and their individual risk profiles.
When you express an interest in our NAD products, you’ll fill in a short form that will give us plenty of information. From there, we decide whether our NAD+ products are suitable for you. If we believe they are, we’ll pass you to one of our board-certified doctors, who will discuss everything with you and find the right NAD dosage per day for you. It’s this approach that adds an extra layer of safety and ensures that you’re getting the optimal NAD benefits according to your personal needs.
Medication Interaction Boundaries
There are some medications that people take that can sometimes interact with high-dose NAD+ supplementation. That’s why it’s so important for you to tell us if you’re on any medications at the first stage of getting in touch. It doesn’t necessarily mean you won’t be able to use our products, it may simply mean that your NAD+ dosage needs tweaking, and perhaps closer supervision to check for any reactions.
For instance, some blood pressure and diabetes medications may need more careful attention, but by letting us know everything, you’re covering all bases.
Future Directions in NAD+ Dosing Science
It’s time to grab your crystal ball and look to the future because science evolves at a rapid pace! That means NAD+ supplementation in a few years may look different to how it looks now. This is a good thing because it means more convenience, ease of use, and probably more NAD benefits over time.
Wearable-Integrated Dosing Systems
One very exciting potential development is wearable-integrated dosage systems. This is a form of advanced biometric monitoring and it can check your metabolic parameters in real-time. From there, a more tailored NAD dosage per day can be identified.
While still in its earliest stages, it’s something to keep a close eye on. In effect, it’s a move toward a more responsive dosage protocol, compared to the static schedule we see now.
Sleep Architecture Feedback Loops
Earlier, we talked about how when your NAD levels are dwindling, you may notice sleep is a little harder to come by. That means when you supplement with NAD+, you’ll probably find yourself getting more shut-eye. This opens the door to innovative technological approaches.
Again, this is still in the early stages, but advanced sleep tracking technologies can adjust doses based on changes to your sleep schedule. It can reduce your NAD dosage per day when REM suppression happens, which could indicate too much NAD. It can also increase your dosage if it notices deep sleep plateaus, which could point toward less than optimal levels.
Final Thoughts: Personalizing Your NAD+ Journey
And there we have it! Everything you need to know about NAD+ dosages. The most standout piece of information here is that everyone is unique, and there isn’t a one-size-fits-all route. But that’s a good thing, because it means your supplementation can be tailored to your specific needs, giving you the best possible outcome.
Maybe you’re fine with energy but your sleep could do with some improvement. Perhaps you don’t have an issue with sleep but your brain is foggy and you can’t focus during the day. Knowing what you want to achieve is a good first step, as that can help your board-certified doctor find the best route forward for you.
At Enovone, your safety is our priority. We’re not about guesswork or following generic guidelines. Instead, we tailor our products to your needs, and we do it the safest way possible. All our products are FDA-approved or compound medications that are prepared by reputable pharmacies. We’re not in the business of putting you at risk or making you feel worse – we’re focused on giving you the results you want, and probably even better!
Imagine – no more sluggish days when energy seems too elusive, and no more brain fog that leaves you wondering if you left the gas on several times a day. Instead, a happier, healthier, and far more energized version of you. Sounds good, right? Reach out to us today and let’s get started on your path to longevity and vitality. And no, it’s not too good to be true!
