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NAD+ Therapy Choices Compared: Should You Drip or Inject?
If you’ve heard about the benefits of NAD+ — increased energy, improved focus, better sleep, and even anti-aging effects — you may be wondering: What’s the best way to get it into your system?
Two of the most popular options are IV drips and at-home NAD+ injections. Both have their merits, but depending on your lifestyle, budget, and health goals, one may be a better fit for you.
Let’s compare.
1. Bioavailability & Effectiveness
Both IV and subcutaneous (under-the-skin) injections bypass the digestive tract, allowing NAD+ to enter the bloodstream directly.
IV Drip Therapy: Delivers NAD+ through a vein over 1–3 hours. Offers 100% bioavailability with immediate circulation.
At-Home Injections: Administered in small daily or every-other-day doses for ongoing cellular support. Also highly bioavailable and supports steady, sustained levels.
🏆 Verdict: Both methods are highly effective. IV may feel stronger up front, but daily injections allow for consistent support without the crash.
2. Convenience & Lifestyle Fit
IV Drips: Require a clinic visit or mobile nurse. Often involves scheduling, travel time, and sitting still for up to 3 hours.
At-Home Injections: Take less than 2 minutes and can be done from the comfort of your home, on your own schedule.
🏆 Verdict: If you’re busy (or just value autonomy), at-home wins hands down.
3. Cost
IV NAD+ Therapy: Typically $400–$750 per session. Monthly routines can easily reach $1,500+.
At-Home Injections: Starting at $115, depending on vial size and monthly vs quarterly pricing.
Verdict: At-home injections offer a much more accessible, sustainable option for most people.
4. Customization & Dosing
IV Drips: Pre-set doses and intervals, typically administered weekly or monthly.
Injections: Allow for microdosing — you can titrate your dose based on how you feel, or what your practitioner recommends.
🏆 Verdict: Injections offer more flexibility and patient-led control over your regimen.
5. Comfort & Experience
IV Drips: Some report mild discomfort during the drip. Others enjoy it as a relaxing spa-like session.
Injections: Involve a tiny needle, but take seconds. Some may experience a slight burning sensation that fades quickly.
🏆 Verdict: Depends on your sensitivity. But for speed and simplicity, injections win again.
So… Should You Drip or Inject?
Both IV drips and at-home injections deliver real, science-backed benefits. But if you’re looking for a more flexible, cost-effective, and empowering way to support your energy, focus, and longevity — at-home NAD+ injections are tough to beat.
They give you:
A fraction of the cost of IV therapy
Total schedule freedom — no clinics, no waiting
Medical-grade quality and safety
Daily support that fits into your routine, not the other way around
Experience the Benefits — Without the Hassle
We believe everyone deserves access to real, science-backed health tools — not just those with time for drip lounges or IV clinics.
That’s why we created our at-home NAD+ injection kits:
Clinically formulated, pharmacy-compounded, and designed to help you feel more like you — every single day.
Authentic Experiences with Proven Outcomes
Karen, San Diego
I was pretty blown away by how energetic and fresh I felt after just a couple of NAD+ injections. Couldn’t recommend it more!
- Verified Enovone Client
Stacy, New York
Enov.one’s service is unbeatable. I had my package within a couple of days and the doctors have answered all of my questions really quickly.
- Verified Enovone Client
Chad, Austin
I used to apply nasal but switched to injections recently. The kits are actually pretty easy to apply and you get used to it quickly. Greater effect.
- Verified Enovone Client
Frequently Asked Questions
Begin by taking our short online assessment. Based on your responses, we’ll determine if you’re eligible for our services and connect you with one of our board-certified doctors for validation, all from the comfort of your home.
All our partner pharmacies are 503A FDA regulated US based pharmacies. There are routine inspections for quality, efficacy, potency, and safety. If approved medications are shipped directly to you in discreet packaging, ensuring privacy and convenience, unless requested otherwise. Shipping is fast and free.
No insurance is required. We offer transparent, out-of-pocket pricing for all our services, including medications, and ongoing care. Ask our care team if your HSA plan applies.
Our services are designed to address a wide range of conditions related to longevity, including fatigue, anxiety, brain fog, mood imbalances, and weight management. Our medical team will evaluate your specific needs and determine the most appropriate treatment plan.
Absolutely. Our care team is always on hand to provide support, answer questions, and help you navigate your health journey. Regular check-ins and adjustments to your treatment plan are part of our commitment to your well-being.
In emergencies, immediately contact 911 or seek in-person care at an urgent care or Emergency Department.
Our commitment to HIPAA compliance includes stringent security measures for protecting PHI. We ensure that all digital systems involved in storing or manipulating PHI employ robust encryption both at rest and in transit, safeguarding your personal information against unauthorized access.
You can manage your subscription or orders through our customer portal. This includes pausing, canceling, or changing your order details before the next shipment is processed.
We offer flexibility in managing subscriptions and one-time purchases. While we can’t accept returns once a product has left the pharmacy, we are committed to addressing any concerns about your order to ensure satisfaction.
Enov.one provides service to 48/50 of the United States. Currently enov.one does not serve: LA, MS. All other states are within our service area.
No, Enovone offers a flat pricing guarantee. Regardless of the dosage required for your treatment plan, the price remains the same, ensuring transparency and affordability in our care.
IMPORTANT SAFETY INFORMATION
& COMMON SIDE EFFECTS
Products requiring a prescription necessitate an online meeting with a qualified healthcare provider, who will assess the suitability of a prescription. Essential safety information is provided further down. The advantages detailed on enov.one derive from studies conducted by independent third parties. The medication is provided under a subscription model, which you are free to terminate whenever you choose. The pricing displayed is for the first month only, thereafter crossed out pricing applies. The actual packaging of the product might vary from the images displayed. Following the assessment of a healthcare professional, please anticipate a processing and shipping duration of 3-5 days.
The most commonly reported side effect is irritation of the area where the injection is administered. If this occurs, consider changing placement on the body or use injections less often. If irritation continues to occur, apply an over-the-counter itch cream, preferably with hydrocortisone, or discontinue use.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See below for important safety information. Benefits outlined on enov.one are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown. Please allow 3-5 days for processing & shipping following medical approval.
*Should you express interest in a product requiring a prescription, Enov.one will facilitate arranging a evaluation with a certified healthcare practitioner. This professional will assess your suitability for the product. If deemed suitable, the practitioner may issue a prescription, which can be filled at one of our affiliated pharmacies unless you specify an alternative.
*Please note that actual packaging may vary from the images displayed.
References:
- Radenkovic D, Reason, Verdin E. Clinical Evidence for Targeting NAD Therapeutically. Pharmaceuticals (Basel). 2020 Sep 15;13(9):247. doi: 10.3390/ph13090247. PMID: 32942582; PMCID: PMC7558103.
- Walzik D, Jonas W, Joisten N, Belen S, Wüst RCI, Guillemin G, Zimmer P. Tissue-specific effects of exercise as NAD+ -boosting strategy: Current knowledge and future perspectives. Acta Physiol (Oxf). 2023 Mar;237(3):e13921. doi: 10.1111/apha.13921. Epub 2023 Jan 10. PMID: 36599416.
- Helman T, Braidy N. Importance of NAD+ Anabolism in Metabolic, Cardiovascular and Neurodegenerative Disorders. Drugs Aging. 2023 Jan;40(1):33-48. doi: 10.1007/s40266-022-00989-0. Epub 2022 Dec 13. PMID: 36510042.
- Bushana PN, Schmidt MA, Rempe MJ, Sorg BA, Wisor JP. Chronic dietary supplementation with nicotinamide riboside reduces sleep need in the laboratory mouse. Sleep Adv. 2023 Dec 20;4(1):zpad044. doi: 10.1093/sleepadvances/zpad044. PMID: 38152423; PMCID: PMC10752388.
- Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D’Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K, Menzies KJ, Auwerx J. NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science. 2016 Jun 17;352(6292):1436-43. doi: 10.1126/science.aaf2693. Epub 2016 Apr 28. PMID: 27127236.
- Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Long-Term Administration of NAD Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016 Dec 13;24(6):795-806. doi: 10.1016/j.cmet.2016.09.013. Epub 2016 Oct 27. PMID: 28068222; PMCID: PMC5668137.