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Immediate Relief

Vaginal Estrogen Cream

5 star reviews Backed by over 10,000 users

This cream restores moisture and elasticity to vaginal tissue, easing dryness, irritation, and discomfort. It helps improve intimacy and urinary health by targeting the root causes of menopausal vaginal changes safely and effectively.

Start with a 3-month Supply

  • Pay With FSA/HSA
  • Compounded in the USA
  • 5 Minute Assessment

$69/month • Billed Quarterly

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If you’re dealing with vaginal dryness, itching, or discomfort during intimacy, vaginal estrogen cream can provide targeted relief by restoring moisture and tissue health where you need it most. It’s often recommended for women who want to improve vaginal elasticity, reduce irritation, and support urinary health without systemic hormone exposure.

This cream is right for you if you want a local, low-dose treatment that works directly on vaginal tissues, is easy to apply, and has a proven safety record for long-term use. It’s especially helpful if other menopausal symptoms are minimal or well-controlled with other therapies.

Our practitioners, specialized in menopause, will review your symptoms and medical history to help suggest the best treatment plan for you.

You can safely use it alongside local hormonal treatments, like vaginal estrogen cream. Please consult with your doctor about any other hormone treatments you are currently taking before starting treatment with JoyfulRX.

The FDA is currently considering removing the black box warning on HRT, as potential benefits, such as reducing dementia risk and bone loss, may outweigh the risks, particularly when treatment is initiated early in menopause.

Some experts suggest the risks may have been overstated in the past. 

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Benefits

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Better Mood

Increased libido

Sex

Quality You Can Trust

Your medication is delivered from a state-licensed pharmacy within our trusted network, ensuring convenient and timely access.

We take pride in quality you can trust—100% plant-based, bioidentical, additive-free, and crafted to support holistic health, ensuring safety and consistency in every compounded lot.

100% Plant Based

No unnecessary fillers, dyes, or synthetic additives.

Bioidentical

Lab-generated hormones that match your body’s natural ones.

Additive Free

No unnecessary fillers, dyes, or synthetic additives.

Holistic Health

Keeps acidity within neutral range for perfect bio-balance.

How To Get Started

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Take Assessment

Take our quick 5 minute assessment and determine your eligibility.

Connect & Consult

Connect online with one of our board-certified doctors for a consultation.

Start Your Journey

Your medication will be shipped to your door, with safe, fast, and free delivery.

Real Women, Real Change. Backed by data.

Rose, San Clemente

I was able to get quick results compared to local HRT doctors. I have loved being part of the program. Brain fog, night sweats, inability to focus- all improved.

  • Verified Joyful Rx Client

Victorie, Temecula

I’ve noticed increased focus and memory, and can get through my to-do list again. Helps me run my family and have them function better!

  • Verified Joyful Rx Client

Sonia, Santa Barbara

I feel more energy and am back on track with my workout routine. I had kinda lost some of that motivation and so I’m feeling great to be back!

  • Verified Joyful Rx Client

5 Minute Assessment

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Frequently Asked Questions

Begin by taking our short online assessment. Based on your responses, we’ll determine if you’re eligible for our services and connect you with one of our board-certified doctors for validation, all from the comfort of your home.

You can safely use it alongside local hormonal treatments, like vaginal estrogen cream. Please consult with your doctor about any other hormone treatments you are currently taking before starting treatment with JoyfulRX.

Menopause causes changes to your body’s hormone production, which in turn causes symptoms like sleeplessness, hot flashes or mood swings. It can also lead to more serious conditions like osteoporosis. Hormone Replacement Therapy (HRT) rebalances hormone levels to get back to the levels that your body was previously producing. 

All our treatments are bioidentical, meaning that they are chemically identical to what your body would be producing. They are extremely effective and completely safe for the vast majority of women. Our providers, specializing in menopause, will be using the medical intake you complete to decide the best treatment plan for you. They remain available to follow up with you anytime.

Menopause causes changes to your body’s hormone production, which in turn causes symptoms like sleeplessness, hot flashes or mood swings. It can also lead to more serious conditions like osteoporosis. Hormone Replacement Therapy (HRT) rebalances hormone levels to get back to the levels that your body was previously producing. 

All our treatments are bioidentical, meaning that they are chemically identical to what your body would be producing. They are extremely effective and completely safe for the vast majority of women. Our providers, specializing in menopause, will be using the medical intake you complete to decide the best treatment plan for you. They remain available to follow up with you anytime.

Menopause causes changes to your body’s hormone production, which in turn causes symptoms like sleeplessness, hot flashes or mood swings. It can also lead to more serious conditions like osteoporosis. Hormone Replacement Therapy (HRT) rebalances hormone levels to get back to the levels that your body was previously producing. 

All our treatments are bioidentical, meaning that they are chemically identical to what your body would be producing. They are extremely effective and completely safe for the vast majority of women. Our providers, specializing in menopause, will be using the medical intake you complete to decide the best treatment plan for you. They remain available to follow up with you anytime.

Yes, all JoyfulRX products are eligible for reimbursement as defined by IRS requirements. Medications prescribed by a licensed provider are eligible to be paid for or reimbursed by your HSA or FSA. Make sure to always check with your provider to confirm that your plan covers them. You can download your invoice to present it when you submit a reimbursement request. Feel free to contact us at support@joyfulrx.com for further assistance.

Not yet, but we offer flexible pricing and payment plans to keep it affordable for you.

JoyfulRX is available in all 50 U.S. states, plus Washington, D.C.

JoyfulRX is available in all 50 U.S. states, plus Washington, D.C.

JoyfulRX is available in all 50 U.S. states, plus Washington, D.C.

IMPORTANT SAFETY INFORMATION
& COMMON SIDE EFFECTS

Products requiring a prescription necessitate an online meeting with a qualified healthcare provider, who will assess the suitability of a prescription. Essential safety information is provided further down. The advantages detailed on enovonestg.wpenginepowered.com derive from studies conducted by independent third parties. The medication is provided under a subscription model, which you are free to terminate whenever you choose. The actual packaging of the product might vary from the images displayed. Following the assessment of a healthcare professional, please anticipate a processing and shipping duration of 3-5 days.

Vaginal estrogen cream is generally well-tolerated, but some women may experience mild irritation, itching, or discharge at the site of application, especially during the first few weeks. Occasional breast tenderness, spotting, or bloating can also occur as the body adjusts to the hormone. These symptoms often improve with consistent use. If irritation persists or side effects become bothersome, adjusting the dosage or frequency—and consulting with a clinician—can usually resolve the issue.

Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*Should you express interest in a product requiring a prescription, Enov.one will facilitate arranging a evaluation with a certified healthcare practitioner. This professional will assess your suitability for the product. If deemed suitable, the practitioner may issue a prescription, which can be filled at one of our affiliated pharmacies unless you specify an alternative.

References

  1. Archer DF, Kimble TD, Lin FDY, Battucci S, Sniukiene V, Liu JH. A randomized, multicenter, double-blind study to evaluate the safety and efficacy of 0.003% estradiol vaginal cream (15 µg/application) in postmenopausal women with vaginal dryness. Journal of Women’s Health. 2018;27(3):231–237. 29447033
  2. Kroll R, Archer DF, Lin Y, Sniukiene V, Liu JH. A randomized, multicenter, double-blind trial of 0.003% estradiol vaginal cream in postmenopausal women with dyspareunia as the most bothersome symptom. Menopause. 2018;25(2):133–138.
  3. De Seta F, Caruso S, Di Lorenzo G, Romano F, Mirandola M, Nappi RE. Efficacy and safety of estradiol vaginal gel in treating vulvovaginal atrophy: a double-blind, randomized, placebo-controlled trial. Maturitas. 2021;147:34–40. 
  4. Simon JA, Archer DF, Constantine GD, Pickar JH, Amadio JM, Bernick B, et al. TX-004HR estradiol vaginal softgel capsule demonstrates negligible systemic absorption: pharmacokinetics and clinical review. Maturitas. 2017;99:51–58. 
  5. Huang AJ, Yaffe K, Vittinghoff E, et al. Systemic estradiol levels following low-dose vaginal estrogens: a pharmacokinetic review. Menopause. 2015;22(4):398–406. 
  6. American Academy of Family Physicians. Vaginal estrogen preparations for relief of atrophic vaginitis: safety and efficacy review. American Family Physician. 2004;69(9):2111–2118. 
  7. European Medicines Agency. Pharmacovigilance Risk Assessment Committee: systemic estradiol exposure from high-strength vaginal cream (100 µg/g) and four-week use limit. EMA Report. 2018. 
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$69/month • Billed Quarterly

5 star reviews Backed by over 10,000 users

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