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What Is NAD+ and Why Is Everyone Talking About It?
If you’ve been feeling more tired than usual, struggling to focus, or simply noticing that your energy just doesn’t bounce back the way it used to — you’re not alone. Many people are turning to NAD+ therapy for support. But what is NAD+, and why is it generating so much buzz?
Let’s break it down.
What Is NAD+?
NAD+ (short for Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell of your body. It plays a key role in:
Cellular energy production (ATP)
DNA repair
Mitochondrial function
Cognitive performance
Healthy aging
Unfortunately, your natural NAD+ levels decline as you age — sometimes by over 50% by your 40s or 50s. This drop is associated with fatigue, slower metabolism, brain fog, poor recovery, and signs of aging.
Why Take NAD+?
Replenishing NAD+ helps restore what time and stress have taken away. Users often report:
✅ Increased daily energy
✅ Sharper focus and mental clarity
✅ Improved sleep and recovery
✅ Better mood and stress resilience
✅ Support for longevity and healthy aging
NAD+ isn’t a stimulant — it works at a cellular level, so benefits feel natural, steady, and compounding over time.
Where Can You Get NAD+?
You won’t find high dose NAD+ in food or typical vitamin stores. Therapeutic doses require medical-grade formulations that are:
Pharmacy-compounded
Prescribed by a licensed provider
Administered either by IV or subcutaneous injection
The two most effective delivery methods are:
IV Drip Therapy — high-dose NAD+ administered in clinics via slow infusion
At-Home Injections — self-administered microdoses that build up NAD+ levels consistently over time
What’s the Best Way to Take NAD+?
It depends on your lifestyle. IV drips offer a strong single dose, but they’re costly, time-consuming, and require a clinic visit.
At-home injections offer:
💉 Simple self-injection in under 2 minutes
⏱️ Flexible daily or every-other-day dosing
💸 Lower cost than IV therapy
🧬 Steady NAD+ support with long-term benefits
Most people prefer at-home NAD+ for its convenience, affordability, and sustained effects.
How to Buy NAD+ Injections from Enov.One
We’ve made it easy to access clinically formulated, pharmacy-compounded NAD+ — all from home.
Here’s how it works:
Online Evaluation
Complete a quick, secure intake reviewed by licensed medical providers.Prescription Approval
If appropriate, your NAD+ therapy will be prescribed by a licensed practitioner.Delivered to Your Door
You’ll receive a full at-home kit with syringes, dosing instructions, and support.
No clinic visits. No waiting rooms. Just expert-guided wellness, on your terms.
Why Enov.One NAD+?
We’re more than just a supplement company — we’re a precision health platform built to help you feel your best, every day.
When you choose Enov.One NAD+, you get:
Pharmacy-grade NAD+ compounded in the U.S.
Medical oversight and personalized support
Discreet, fast delivery with everything you need
Flexible subscriptions, cancel anytime
A trusted team focused on energy, focus, and longevity
Your cells deserve better fuel. Give them what they need to thrive.
Authentic Experiences with Proven Outcomes
Karen, San Diego
I was pretty blown away by how energetic and fresh I felt after just a couple of NAD+ injections. Couldn’t recommend it more!
- Verified Enovone Client
Stacy, New York
Enov.one’s service is unbeatable. I had my package within a couple of days and the doctors have answered all of my questions really quickly.
- Verified Enovone Client
Chad, Austin
I used to apply nasal but switched to injections recently. The kits are actually pretty easy to apply and you get used to it quickly. Greater effect.
- Verified Enovone Client
Frequently Asked Questions
Begin by taking our short online assessment. Based on your responses, we’ll determine if you’re eligible for our services and connect you with one of our board-certified doctors for validation, all from the comfort of your home.
All our partner pharmacies are 503A FDA regulated US based pharmacies. There are routine inspections for quality, efficacy, potency, and safety. If approved medications are shipped directly to you in discreet packaging, ensuring privacy and convenience, unless requested otherwise. Shipping is fast and free.
No insurance is required. We offer transparent, out-of-pocket pricing for all our services, including medications, and ongoing care. Ask our care team if your HSA plan applies.
Our services are designed to address a wide range of conditions related to longevity, including fatigue, anxiety, brain fog, mood imbalances, and weight management. Our medical team will evaluate your specific needs and determine the most appropriate treatment plan.
Absolutely. Our care team is always on hand to provide support, answer questions, and help you navigate your health journey. Regular check-ins and adjustments to your treatment plan are part of our commitment to your well-being.
In emergencies, immediately contact 911 or seek in-person care at an urgent care or Emergency Department.
Our commitment to HIPAA compliance includes stringent security measures for protecting PHI. We ensure that all digital systems involved in storing or manipulating PHI employ robust encryption both at rest and in transit, safeguarding your personal information against unauthorized access.
You can manage your subscription or orders through our customer portal. This includes pausing, canceling, or changing your order details before the next shipment is processed.
We offer flexibility in managing subscriptions and one-time purchases. While we can’t accept returns once a product has left the pharmacy, we are committed to addressing any concerns about your order to ensure satisfaction.
Enov.one provides service to 48/50 of the United States. Currently enov.one does not serve: LA, MS. All other states are within our service area.
No, Enovone offers a flat pricing guarantee. Regardless of the dosage required for your treatment plan, the price remains the same, ensuring transparency and affordability in our care.
IMPORTANT SAFETY INFORMATION
& COMMON SIDE EFFECTS
Products requiring a prescription necessitate an online meeting with a qualified healthcare provider, who will assess the suitability of a prescription. Essential safety information is provided further down. The advantages detailed on enov.one derive from studies conducted by independent third parties. The medication is provided under a subscription model, which you are free to terminate whenever you choose. The pricing displayed is for the first month only, thereafter crossed out pricing applies. The actual packaging of the product might vary from the images displayed. Following the assessment of a healthcare professional, please anticipate a processing and shipping duration of 3-5 days.
The most commonly reported side effect is irritation of the area where the injection is administered. If this occurs, consider changing placement on the body or use injections less often. If irritation continues to occur, apply an over-the-counter itch cream, preferably with hydrocortisone, or discontinue use.
Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See below for important safety information. Benefits outlined on enov.one are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown. Please allow 3-5 days for processing & shipping following medical approval.
*Should you express interest in a product requiring a prescription, Enov.one will facilitate arranging a evaluation with a certified healthcare practitioner. This professional will assess your suitability for the product. If deemed suitable, the practitioner may issue a prescription, which can be filled at one of our affiliated pharmacies unless you specify an alternative.
*Please note that actual packaging may vary from the images displayed.
References:
- Radenkovic D, Reason, Verdin E. Clinical Evidence for Targeting NAD Therapeutically. Pharmaceuticals (Basel). 2020 Sep 15;13(9):247. doi: 10.3390/ph13090247. PMID: 32942582; PMCID: PMC7558103.
- Walzik D, Jonas W, Joisten N, Belen S, Wüst RCI, Guillemin G, Zimmer P. Tissue-specific effects of exercise as NAD+ -boosting strategy: Current knowledge and future perspectives. Acta Physiol (Oxf). 2023 Mar;237(3):e13921. doi: 10.1111/apha.13921. Epub 2023 Jan 10. PMID: 36599416.
- Helman T, Braidy N. Importance of NAD+ Anabolism in Metabolic, Cardiovascular and Neurodegenerative Disorders. Drugs Aging. 2023 Jan;40(1):33-48. doi: 10.1007/s40266-022-00989-0. Epub 2022 Dec 13. PMID: 36510042.
- Bushana PN, Schmidt MA, Rempe MJ, Sorg BA, Wisor JP. Chronic dietary supplementation with nicotinamide riboside reduces sleep need in the laboratory mouse. Sleep Adv. 2023 Dec 20;4(1):zpad044. doi: 10.1093/sleepadvances/zpad044. PMID: 38152423; PMCID: PMC10752388.
- Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D’Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K, Menzies KJ, Auwerx J. NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science. 2016 Jun 17;352(6292):1436-43. doi: 10.1126/science.aaf2693. Epub 2016 Apr 28. PMID: 27127236.
- Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Long-Term Administration of NAD Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016 Dec 13;24(6):795-806. doi: 10.1016/j.cmet.2016.09.013. Epub 2016 Oct 27. PMID: 28068222; PMCID: PMC5668137.