Do you feel it? That bottoming-out in your energy levels. That feeling – that they’re simply not what they used to be when you were younger. Overall, it’s a common story – across the board- and there’s real science behind it. Studies show our natural levels of a vital coenzyme called NAD+ can decline significantly as we age. This leads to fatigue and brain fog. Because of this, many people are exploring NAD+ therapy to help recharge their cellular batteries.
The world of NAD+ therapy has grown incredibly fast. You can now find many different approaches, from powerful injections to needle-free options. While having so many choices is great, it can feel overwhelming to figure out which path is safe, effective, and backed by real medical support.
That’s exactly why we created this guide. We’ve done the deep research on the entire NAD+ landscape, focusing on the Orlando area and the top at-home programs. We’ll help you understand what to look for so you can find a service that offers genuine medical guidance and results you can feel.
Table of Contents
TL;DR: Quick Overview
Don’t have time for the full breakdown? Here are the NAD+ clinics’ highlights to help you get started :
- Best Overall: Enovone stands out with its perfect scores, offering a complete at-home NAD+ program that includes doctor-led care, multiple delivery methods, and clear, flat-rate pricing
- Best for In-Clinic IVs: Restore Hyper Wellness is a great choice for those who prefer receiving their NAD+ IV therapy in a professional, clinical environment with standardized procedures
- Best for Memberships: Serotonin Centers offers a unique membership model for its NAD+ services, providing predictable costs and ongoing support for those committed to a long-term plan
- Best for At-Home IVs: Drip Hydration brings a licensed nurse to your home to administer IVs, combining the power of a drip with the comfort of being at home
- Best for a Spa-Like Feel: Spa Blue integrates NAD+ therapy into a holistic wellness and spa setting, perfect for those who want a relaxing and comprehensive experience
- Most Flexible Service: With multiple dosage levels and house call options, Ageless Aesthetics offers a highly customizable approach to NAD+ IV therapy
- Best for Brain Health: Florida Mind Health provides specialized NAD+ protocols specifically designed to support cognitive function and mood
Comparison Table
NAD+ Clinics | Medical Supervision | Treatment Options | Convenience | Pricing | Safety Standards | Customer Support | Overall Score |
Enovone | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 5/5 | 30/30 |
Restore Hyper Wellness | 4/5 | 3/5 | 4/5 | 3/5 | 4/5 | 4/5 | 22/30 |
Spa Blue | 4/5 | 4/5 | 3/5 | 3/5 | 4/5 | 4/5 | 22/30 |
Affinity Med Spa | 5/5 | 4/5 | 3/5 | 3/5 | 4/5 | 4/5 | 23/30 |
Serotonin Centers | 4/5 | 4/5 | 4/5 | 4/5 | 4/5 | 4/5 | 24/30 |
Drip Hydration | 4/5 | 5/5 | 5/5 | 4/5 | 4/5 | 3/5 | 25/30 |
Florida Mind Health | 4/5 | 3/5 | 3/5 | 3/5 | 4/5 | 3/5 | 20/30 |
Criteria Breakdown Summary
Choosing the right NAD+ clinic or service comes down to a few key factors that have a big impact on your safety and results. Here’s what we believe is most important to look for –
- Medical Supervision – This is our number one factor. A real, board-certified doctor should be involved in your care to create a safe, personal plan, especially when dealing with injections or IVs
- Treatment Options – The best services offer flexibility. While some clinics only provide one type of therapy (like IVs), providers with multiple options (injections, nasal sprays, creams) can better tailor the treatment to your comfort and lifestyle
- Convenience – A good wellness plan should fit into your life, not complicate it. We prioritized services that make it simple to get started and offer convenient at-home options to avoid travel and waiting rooms
- Pricing & Transparency -There shouldn’t be any financial surprises on your health journey. We favored services with clear, upfront pricing, especially those with flat-rate or subscription models that make budgeting easy
- Safety & Quality Standards – Knowing what’s in your vial is essential. We looked for services that partner with FDA-regulated 503A pharmacies in the U.S. to ensure you’re getting a high-quality, sterile product
- Customer Support – When you have a question, you want a real person to talk to. We looked for services that offer responsive, accessible support from a knowledgeable team
Enovone - Best Known for Comprehensive At-Home Solutions
When we looked at the world of NAD+ therapy, we saw a need for a simpler, safer, and more supportive way for people to access it. That’s why we created the Enovone program. We built it from the ground up to be a complete at-home solution that puts real medical guidance at the center of everything.
Your journey with us starts with a quick online assessment so we can understand your health goals. From there, you’ll have a private telehealth consultation with a board-certified doctor who will create your personal plan. We focus on providing NAD+ for energy and revitalization, and our entire process is designed to be supportive and straightforward.
Our goal is to make your at-home NAD+ clinics experience simple and supportive.
Source: enov.one
Features
Here’s what makes our approach different –
Doctor-Led, Always – Your entire journey is guided by a board-certified doctor. We believe this is the only safe and effective way to approach NAD+ therapy
Clear, Flat-Rate Pricing – We have one simple monthly price. Your fee never changes based on your dose, so you can focus on your health without worrying about surprise costs
Convenience Without Compromise – Your complete treatment kit – including sterile supplies – is shipped discreetly from our partner pharmacy right to your door
Support You Can Count On – Have a question? Our medical support team is available 24/7 through our secure HIPAA-compliant platform to provide guidance whenever you need it
A Focus on You – We offer several ways to take NAD+, including our popular NAD+ injections, a convenient nasal spray, and our advanced NAD+ Face Cream
Pros
- A Doctor is Your Co-Pilot. From your first consultation to ongoing check-ins, your entire plan is managed by a board-certified doctor who gets to know you and your goals
- Total Pricing Clarity. We believe in simple, predictable pricing. Our flat-rate monthly fee means the cost stays the same, even if your doctor adjusts your dose
- Wellness That Comes to You. Your complete treatment kit, including all sterile supplies, is shipped discreetly to your home, so you never have to plan your day around a clinic visit
Cons
- It’s a Virtual-First Experience. Our entire process is designed for the convenience of virtual care. This is perfect for busy lifestyles but might not be the right fit if you strongly prefer seeing a doctor face-to-face
- State Limitations Exclude Louisiana and Mississippi Residents from Service. Regulatory requirements in these states prevent telemedicine NAD+ prescribing.
- You’re in Control of Injections. A key part of our at-home plan is learning to self-administer your injections. We provide clear video guides and full support to make this easy, but it’s an important skill for this program
Criteria Evaluation
- Medical Supervision & Credentials: 5/5
- Treatment Options & Delivery Methods: 5/5
- Convenience & Accessibility: 5/5
- Pricing & Value: 5/5
- Safety & Quality Standards: 5/5
- Customer Support & Follow-up Care: 5/5
Community Reviews
Here’s what our clients are saying – we’re proud of the feedback we receive –
“I was pretty blown away by how energetic and fresh I felt after just a couple of NAD+ injections. Couldn’t recommend it more!” -Karen, San Diego, verified Enovone client
“Enov.one’s service is unbeatable. I had my package within a couple of days and the doctors have answered all of my questions really quickly.” – Stacy, New York, verified Enovone client
“I used to apply nasal but switched to injections recently. The kits are actually pretty easy to apply and you get used to it quickly. Greater effect.” – Chad, Austin, verified Enovone client
Price
We believe in being upfront about costs. Our program has a flat-rate monthly fee, and your specific pricing is provided after your medical consultation. We include free shipping and accept HSA/FSA payments.
Restore Hyper Wellness (Orlando) - Best Known for Clinical IV Therapy
Restore Hyper Wellness is a well-known brand in the wellness space, offering a variety of “biohacking” services in a professional, clinical setting. Their Orlando location is a great example of their approach, where NAD+ IV drip therapy is one of many treatments available, alongside things like cryotherapy and red light therapy. This is a great choice for people who want a one-stop-shop for different wellness treatments and prefer being in a physical clinic for their services.
While you’re here, check out NAD+ side effects to help you understand the full picture of any therapy.
Many NAD+ clinics offer a professional, in-person experience for those who prefer a traditional setting.
Source: restore.com
Features
Here’s what you can expect from this NAD+ clinic –
- In-clinic NAD+ IV infusions
- Offers a wide menu of other wellness services
- Medical expert supervision during treatments
- Standardized protocols across their many locations
Pros
- The clinical atmosphere feels professional and reassuring
- It’s an established brand with a consistent approach
- Staff are experienced and can answer questions during treatment
Cons
- The service is limited to IV therapy only, with no injection options
- Requires in-person appointments in Orlando, FL, which means travel and scheduling
Criteria Evaluation
- Medical Supervision & Credentials: 4/5
- Treatment Options & Delivery Methods: 3/5
- Convenience & Accessibility: 4/5
- Pricing & Value: 3/5
- Safety & Quality Standards: 4/5
- Customer Support & Follow-up Care: 4/5
Community Reviews
Here’s what people are saying about their experience –
“Restore is an amazing place to support your health wellness. From the moment you walk in and are greeted by the friendly, courteous and warm staff;..” –Licette Nieves, Google reviews
“Do not waste your money. Be careful with your credit card they don’t understand cancel and continued to charge my card and told me my points expired.” –Orchid Friend, Google reviews
Price
You’ll need to contact the specific Orlando location for pricing. They often offer packages for multiple sessions
Spa Blue (Orlando) - Best Known for Holistic Wellness Integration
Spa Blue takes a comprehensive approach to NAD+ therapy, integrating treatments with broader wellness protocols. They don’t just offer a single treatment – they look at your overall health to create a personalized protocol that can include a blend of vitamins and minerals alongside your NAD+ IV therapy. This is a great choice for someone who wants a truly holistic plan designed by a healthcare team in a comfortable spa setting.
But with so many options, could there be NAD IV hidden truths that clinics don’t want you to know? It’s always good to be informed.
Spa Blue is an NAD+ clinic with a different approach to NAD+ therapy that can help minimize side effects.
Source: orlandospablue.com
Features
Here’s what makes their approach –
- Personalized NAD+ IV therapy sessions
- Combination treatments that blend vitamins and minerals
- Focus on anti-aging and regenerative medicine
- Comprehensive health consultations before starting
Pros
- A holistic approach that looks at your overall health
- Very personalized plans designed just for you
- The healthcare team is experienced with complex combination therapies
Cons
- Limited to the Orlando area
- This highly customized approach can be more expensive and complex to schedule
Criteria Evaluation
- Medical Supervision & Credentials: 4/5
- Treatment Options & Delivery Methods: 4/5
- Convenience & Accessibility: 3/5
- Pricing & Value: 3/5
- Safety & Quality Standards: 4/5
- Customer Support & Follow-up Care: 4/5
Community Reviews
For NAD+ locations in Orlando, here’s what people are saying about their various services –
“I’ve been coming here for the last few years and I adoreee Janet. She is super friendly and so good at her job. She has actual technique when injecting..” – Tatjana Glushko, Google reviews
“BEWARE!!! DO NOT book any appointment at Spa Blue. The owner Janet is a poor unprofessional business person.” –Crystal Cardwell, Google reviews
Price
Pricing is customized based on the complexity of your unique treatment plan.
Affinity Med Spa and Wellness Center - Best Known for Expert Medical Supervision
At Enovone, we understand the science behind metabolic regeneration when it comes to NAD+ Peptide dosage. That said, Affinity Med Spa stands out because of the deep expertise of its medical director, Dr. John A. Robinson. With over 20 years of experience in longevity medicine, this clinic offers scientifically-backed NAD+ protocols that go far beyond a basic drip. Their focus is on subcutaneous NAD+ injections, which is a different approach from clinics that only offer IV therapy.
A specialist can provide a highly targeted plan from the top NAD+ clinics.
Source: myaffinitymedspa.com
Features
Here are some of the features of this practice –
- Subcutaneous NAD+ injections (not IVs)
- Protocols are personally overseen by a board-certified physician
- Integrates sirtuin-activating compounds to complement NAD+
- Includes personalized diet and exercise programs
Pros
- Their model is built around the direct supervision of a board-certified physician with a specific background in longevity medicine
- Their treatment plans often include diet and exercise recommendations to complement the NAD+ therapy
- The clinic’s approach is rooted in the doctor’s two decades of experience specifically within the field of longevity medicine
- Their treatment decisions are grounded in clinical data and research from the longevity field
Cons
- Limited to the Orlando area and requires in-person visits
- This level of expertise comes with premium pricing
Criteria Evaluation
- Medical Supervision & Credentials: 5/5
- Treatment Options & Delivery Methods: 4/5
- Convenience & Accessibility: 3/5
- Pricing & Value: 3/5
- Safety & Quality Standards: 4/5
- Customer Support & Follow-up Care: 4/5
Community Reviews
When looking at various NAD+ clinics in Orlando, here’s what you’ll find from the reviews of Affinity Med Spa –
“I have never been to a Med Spa before and I’m so glad that Affinity was my first experience and most likely my only experience because I was blown away with the services and the service.” – Maurice Bullard, Google reviews
“I was very badly bruised when the nurse practitioner took my blood. And my left knee has not stopped hurting since last prf injection.” – Judith Vega, Google reviews
Price
Requires a consultation for an individualized quote based on a comprehensive plan.
Serotonin Centers - Best Known for Membership-Based Care
Serotonin Centers also takes a “one-stop-shop” approach to wellness, using a membership model for its services. Their program includes at-home NAD+ injections as part of a broader menu of ‘biohacking’ treatments. For a predictable monthly fee, members get access to these therapies with clinical guidance from nurse practitioners and lifestyle support from health coaches.
Some NAD+ clinics offer both IV therapy and at-home injections – like Serotonin Centers.
Source: serotonincenters.com
Features
Let’s take a look at what the membership includes –
- Offers both in-clinic IV therapy and at-home injection options
- A flat-rate monthly membership program
- Includes support from a health coach to help with lifestyle factors
- Nurse practitioners provide clinical guidance
Pros
- The membership model offers predictable costs, which is great for budgeting
- The inclusion of health coaching adds a layer of holistic support
- They offer both at-home and in-clinic options, which is flexible
Cons
- The membership model requires a longer-term commitment
- Service is limited to their specific geographic locations
Criteria Evaluation
- Medical Supervision & Credentials: 4/5
- Treatment Options & Delivery Methods: 4/5
- Convenience & Accessibility: 4/5
- Pricing & Value: 4/5
- Safety & Quality Standards: 4/5
- Customer Support & Follow-up Care: 4/5
Community Reviews
Here’s the word from those who’ve tried this NAD+ clinics option –
“This place is a life changer and all the girls are phenomenal! Andrea and Taylor are extremely professional and have made my experience very welcoming and enjoyable..” –Keith Conklin, Google reviews
“Be VERY careful of what you agree to from this company. They will set you up on one plan and then they will charge you for another. You will attempt to cancel your contract and they will continue to charge you…” –Emily Krell Krell, Google reviews
Price
Their at-home injection program is advertised at a flat monthly fee of $299.
Drip Hydration - Best Known for Multiple Delivery Methods
With NAD+ IV therapy, injections, and nasal spray administered by registered nurses at home through Drip Hydration is all about flexibility and convenience. They’re best known for their mobile IV service, where a nurse comes to your home or office, making them a top choice for convenience across the country.
Their biggest strength is offering a full range of delivery methods. You can choose a powerful, though time-intensive, 3-4 hour IV infusion, a quick subcutaneous injection, or a needle-free nasal spray. This allows you to find the perfect fit for your lifestyle and comfort level, all while having a medical professional handle the administration.
NAD+ clinics such as this one in Orlando, FL, give you more than one option for administration.
Source: driphydration.com
Features
Here’s what to know about Drip Hydration –
- Offers IV infusions, subcutaneous injections, and nasal sprays
- Registered nurses come to your home to administer treatments
- Their service is available in dozens of major cities across the U.S
- Their IV infusions are thorough, often lasting 3-4 hours
Pros
- Maximum flexibility with a full range of delivery methods
- Very convenient at-home service with a medical professional
- They have a wide service area covering many major metro areas
Cons
- The long IV infusion times (3-4 hours) can be a significant time commitment
- Follow-up support between visits is more limited than some other services
- Only located in 80 cities across the nation
Criteria Evaluation
- Medical Supervision & Credentials: 4/5
- Treatment Options & Delivery Methods: 5/5
- Convenience & Accessibility: 5/5
- Pricing & Value: 4/5
- Safety & Quality Standards: 4/5
- Customer Support & Follow-up Care: 3/5
Community Reviews
Here’s what folks are saying about this at-home service –
“I’ve been using this home IV service for a while now, and I’m consistently impressed by the professionalism and care shown by every nurse who visits. Each one has been friendly, punctual, and incredibly skilled..” – Anonymous reviewer, Google Reviews
“While my nurse, Jill, was polite and communicated well at first, the overall experience with Drip Hydration in Boston was disappointing. She came unprepared and had to leave to retrieve additional supplies. When she returned, she attempted to insert an IV five separate times, leaving me bruised and in pain…” –Anonymous reviewer, Google reviews
Price
Varies depending on which treatment method you choose.
Florida Mind Health - Best Known for Brain Health Focus
We know that getting the right NAD+ dosage per day matters. That said, Florida Mind Health has carved out a unique specialty by focusing its NAD+ therapy specifically on supporting brain function and mental health. Their targeted approach is ideal for patients whose primary goals are cognitive enhancement and mood support.
This is a great example of a specialized practice for those who want a doctor who is an expert in the neurological effects of NAD+, which can be helpful for conditions like depression, anxiety, or persistent brain fog.
NAD+ clinics include Florida Mind Health.
Source: flmindhealth.com
Features
Here’s a look at their approach –
- A specialized focus on brain health, cognition, and mood
- Medical supervision with expertise in mental health applications
- Uses nicotinamide riboside (NR), a precursor to NAD+
Pros
- Targeted expertise for people with specific cognitive or mood concerns
- Clinical oversight ensures treatments are safely integrated with any existing mental health care
Cons
- The narrow focus isn’t for those looking for general wellness or physical energy benefits
- Geographically limited to their local area
Criteria Evaluation
- Medical Supervision & Credentials: 4/5
- Treatment Options & Delivery Methods: 3/5
- Convenience & Accessibility: 3/5
- Pricing & Value: 3/5
- Safety & Quality Standards: 4/5
- Customer Support & Follow-up Care: 3/5
Community Reviews
Here’s what we’ve found from reviews for Florida Mind Health –
“I went for my first IV infusion with Florida Mind Health Center. The staff (Desiree) and Dr. Zohar was very professional and compassionate, I could not rave enough to my family and friends about how friendly the two were and GHS atmosphere was impeccable. I got my vitamin booster and been feeling energized all week. This is now my new got to place to get recharged.” Deidra V., Yelp reviews
“Took my wife there for infusions. Great experience! She was very well taken care of” – Dan Shields, Google reviews
Price
Requires a consultation for a specialized treatment plan.
Notable Mentions
While the 7 clinics for NAD+ above are at the top, here’s some noteworthy mentions you may want to consider –
Restore Hyper Wellness (Other Locations)
Beyond the Orlando location we reviewed, Restore is a national franchise. Their standardized approach means you can often get a reliable quality of treatment in different cities. So, whether it’s NAD injections in NYC you’re looking for, or beyond, there’s often local options with a known brand name.
Local Compounding Pharmacies
Many regional pharmacies now prepare NAD+ formulations with a doctor’s prescription. This is often the most affordable route if you already have a trusted relationship with a doctor who can write the prescription and manage your care independently.
Integrative Medicine Clinics
Functional medicine doctors are increasingly using NAD+ therapy as part of a larger, holistic health plan. These clinics are great for getting to the root cause of health issues, as they often do very thorough health assessments, but they can have longer wait times and higher costs.
Wellness Centers with IV Lounges
The growing IV lounge trend often includes NAD+ therapy on their menu. While these can be convenient for a quick drip, it’s incredibly important to check who is providing the medical supervision, as the quality and safety standards can vary widely.
Frequently Asked Questions
What Should I Look for in NAD+ Clinic Safety Standards?
Safety standards matter, just as much as dried blood spot sampling is among the top NAD+ level tests that actually work. That said, when it comes to an NAD+ clinic’s safety, a great plan always starts with a great doctor.
Look for services that have board-certified physicians overseeing their programs. The highest quality providers partner with FDA-regulated 503A pharmacies in the U.S., which means the NAD+ you receive is sterile and potent. A quality clinic will always conduct a thorough health assessment before starting you on a plan and will be transparent about their safety protocols.
How Do NAD+ Clinic Costs Compare Across Different Providers?
Just like learning a lot about Joe Rogan’s NAD+ supplement craze from going down the rabbit hole, you can also find out quite a bit about how dramatically NAD+ clinic costs vary. The price spectrum is huge. An in-person IV session at a city clinic can cost anywhere from $200 to over $800, while a monthly subscription for an at-home program is often a more predictable flat rate.
When comparing, be sure to look at the total cost. Factor in any consultation fees, the cost of supplies, and your own travel time. Often, at-home telemedicine services provide the best overall value because they cut out the overhead costs of a physical clinic.
Which NAD+ Delivery Method Is Most Effective?
If you’re attempting to boost your NAD+ levels, there are a few delivery methods worth considering – everyone is different. IV therapy offers 100% absorption, but it requires a long session in a clinic. Subcutaneous injections are a close second with around 90% absorption, but they are much faster and more convenient for at-home use. Needle-free options like nasal sprays have lower absorption but are a fantastic choice for those with needle anxiety.
However, at Enovone, we believe the “most effective” method is the one that’s part of a safe, doctor-led plan that you can stick with consistently.
Do Insurance Plans Cover NAD+ Therapy?
Generally, no. Most insurance plans consider NAD+ therapy to be a wellness or preventative treatment rather than “medically necessary,” so it’s usually an out-of-pocket expense. Sometimes, looking into the best NAD+ injection reviews and alternatives can help you find a high-quality plan and pricing model that works comfortably for your budget. You can also check if your HSA/FSA account can be used, as many medically supervised programs qualify.
How Long Does It Take to See Results from NAD+ Therapy?
Seeing results all depends on what NAD+ does for your body. As your body’s master energy conductor, you’ll tend to see improvements in your energy levels within the first week or two. Many people report feeling a more stable, natural energy and better sleep quality first. Sharper focus often follows, while the deeper anti-aging benefits for your cells build up over several months of consistent use.
Final Thoughts
At Enovone, we love seeing what our NAD+ 1000mg can do for others. The before and after with NAD+ therapy can be truly remarkable when your plan is safe, consistent, and tailored to you.
After looking at all the options for NAD+ clinics, the most important takeaway is that the quality of your medical support matters more than anything else.
Whether you’re debating on NAD+ injections vs IV therapy or simply ready to get started with NAD+ injections, we’re here to guide you. The best providers have moved beyond the basic spa model to offer real, doctor-led care.
For those seeking convenient, professionally supervised NAD+ therapy, we designed our telehealth platform to be the solution. If you’re ready to experience that difference, your path starts here.
Begin by taking our quick online assessment. It’s a simple way for us to learn about your goals and match you with the right support. If we’re a good match, we’ll set up a one-on-one telehealth visit with one of our board-certified doctors to talk about your personal plan. No travel, no waiting rooms – just expert care, delivered to you.