You feel it, don’t you? That slow drain. The days when your focus feels fuzzy and your energy just isn’t what it used to be. It’s a common story. But it doesn’t have to be yours.
You’re here because you know there’s a better way. You’ve heard the buzz about NAD+. It’s this incredible molecule that powers your cells, boosts longevity, and helps you feel like the best version of yourself. It sounds amazing, because it is.
But getting it right is key. You can’t just take a random amount and hope for the best before and after. That’s where we come in. This guide will break down everything you need to know about the right NAD+ dosage per week for you – giving you the straight-up facts.
At Enovone, your vitality is our number one priority. Let’s start this journey together and find the perfect plan for you.
Table of Contents
TL;DR
- It’s a vital coenzyme that powers your cells for energy, DNA repair, and healthy aging. Your natural levels drop as you get older
- Since your body uses NAD+ quickly, a weekly plan with smaller, more frequent injections often works better than one huge dose
- The perfect NAD+ dosage per week depends on your age, health goals, genetics, and lifestyle. Personalization is everything
- Taking your NAD+ in the morning can align with your body’s natural rhythms, potentially boosting its effects
- Keeping a simple journal of your energy, sleep, and focus is the best way to see what’s working and fine-tune your dose
- Working with a doctor helps you find a safe, effective protocol designed just for you
Your NAD+ dosage works best when supported by positive lifestyle choices.
Source: biorestorehealth.com
Fundamentals - Why NAD+ Dosage Matters
Okay, let’s start with the basics. What exactly is NAD+ and why is getting the NAD+ dosage right so important?
Think of NAD+ (Nicotinamide Adenine Dinucleotide) as the spark plug for your cells. It’s a critical coenzyme. That means it helps other enzymes do their jobs. It’s involved in over 500 different reactions in your body. The most important ones?
- Creating Energy – It helps turn the food you eat into cellular energy (ATP). More NAD+ means more energy. Simple as that.
- Repairing DNA – It powers proteins called sirtuins and PARPs, which act like a cellular repair crew for your DNA.
- Regulating Health – It plays a huge role in everything from your metabolism to your immune response and circadian rhythm.
Here’s the catch – your NAD+ levels naturally decline as you age. As Coveteur magazine notes, “Research shows NAD+ plays a pivotal role in cell regeneration. NAD levels decline with age, beginning in the early 30s, and recent studies suggest levels decline even earlier in some individuals. As NAD levels decrease, cells begin to die.”
This decline is why you might feel more tired or notice your recovery isn’t as quick as it once was. Supplementation with a high-quality NAD+ injection is the most direct way to restore these levels. But it’s not about flooding your system. It’s about giving your cells the precise amount of fuel they need to thrive.
Before starting any routine, it’s essential to get the basics down. For those new to this, our starting guide on NAD+ injections provides great info.
Finding Your Starting Point - Half-Life and Thresholds
You might be wondering, “Why can’t I just take one big dose on Monday and be good for the week?”. The answer lies in two key concepts: half-life and metabolic thresholds.
Your Body Uses NAD+ Fast
Your body metabolizes NAD+ very quickly. It has a short half-life of about 2-4 hours. This means a single dose doesn’t stick around for long. After a few hours, the level in your bloodstream has dropped by half.
This is why your NAD+ injection dose frequency is often more important than the total amount.
Think of it like this – if you try to get your whole week’s worth of NAD+ from a single large injection, you’ll likely feel a powerful rush of energy at first. But because your body uses it so fast, that feeling can fade quickly, leaving you in a slump for the rest of the week. This is a classic “rollercoaster effect.”
A much smarter approach is to create stability. By splitting that total weekly amount into smaller, more frequent injections – like 100 mg three times a week – you get consistent, reliable energy and focus day in and day out. This lets you create a perfect rhythm that works in sync with your body’s metabolism.
You Need to Reach a "Threshold"
NAD+ works on a threshold effect. This means you need to reach a certain concentration in your cells to “turn on” the good stuff, like those sirtuin repair proteins. If your dose is too low, you won’t cross that threshold, and you won’t get the full benefits. If it’s unnecessarily high, you might just be wasting it.
The goal of a weekly dosing strategy is to keep your NAD+ levels consistently above this beneficial threshold. It’s about creating a steady state of cellular optimization, not a series of peaks and valleys.
Healthy habits like these help your body make the most of every NAD+ dose.
Source: ivdrips.com
Creating Your Personal Plan: Assessment and Customization
This is where it all comes together, and it’s the most important part. At Enovone, we have a core belief – everyone deserves their own health algorithm. This means there’s no such thing as a one-size-fits-all NAD+ dosage. Your perfect plan is as unique as you are. That’s why our data-driven approach always starts with a thorough, personal assessment.
Here’s what goes into creating your custom protocol:
- Your Health Goals – Are you looking for more energy? Better athletic recovery? Sharper focus? Your goal shapes the strategy.
- Your Current Health – We look at key health markers. This includes things like inflammation levels, metabolic health, and oxidative stress. A comprehensive blood analysis can establish your baseline health before you even start.
- Your Genetics – Believe it or not, small variations in your genes can affect how you use NAD+. Some people naturally recycle it more efficiently than others. Understanding this can help fine-tune your dosage for incredible results.
For a deeper understanding of how these factors influence your treatment, explore our article on the importance of genetics in personalized healthcare.
While all these factors are important, your age is one of the biggest drivers in determining the right starting point:
How Your Age Shapes Your Dosing Plan
Your body’s need for NAD+ changes significantly throughout your life. A strategy that works in your 30s won’t be the right fit for your 60s. Here’s a general look at how protocols are tailored for different life stages:
Youth-Focused Protocols (20-40 years)
In your younger years, the focus is usually on prevention and optimization. You likely won’t need a high dose. A lower-dose plan of 50-100mg, taken 2-3 times a week, can be perfect for boosting athletic recovery, sharpening focus for your career, and getting ahead of age-related decline.
Mid-Life Transition Dosing (40-60 years)
This is when many people first notice a significant drop in energy and focus. Your protocol will be more focused on restoration. Doses of 100-150 mg administered 3-4 times a week can help combat fatigue and support cellular repair during this important transition.
Longevity-Focused Geriatric Protocols (60+ years)
Older individuals typically see the most profound benefits from robust NAD+ support. Due to naturally lower levels, a consistent plan is key. As Health.com tells us, a 2023 early-stage clinical trial found that a high dose of a NAD precursor (1500 milligrams of NR twice a day) improved NAD levels and certain Parkinson’s symptoms. For this reason, a plan with 150-200 mg doses taken 3-5 times a week can be ideal for supporting long-term neurological and metabolic health.
Tracking Biomarkers and Symptoms
While directly measuring NAD+ can be tricky, we can track other biomarkers that tell us how it’s working. We also pay close attention to how you feel. Symptom-based titration is a powerful tool. We start with a moderate dose and adjust based on your feedback.
- Are you sleeping better?
- Is your mind clearer?
- Do you feel more resilient to stress?
This combination of hard data and your personal experience helps us dial in the perfect NAD+ dosage per day. A typical prescribed NAD+ dose is 5mg to 10mg daily, but your ideal amount will be tailored to you.
To get a clear picture of your cellular health, your doctor will look at several key biomarkers, such as –
Assessment Parameter | Relevance to NAD+ Dosing | Optimal Range |
NAD+/NADH Ratio | Indicates cellular redox state and metabolic efficiency | 3:1 to 10:1 |
Lactate/Pyruvate Ratio | Indirect measure of NAD+ availability | <10:1 |
NAMPT Expression | Rate-limiting enzyme in NAD+ salvage pathway | Age-dependent |
CD38 Activity | Primary NAD+ consuming enzyme | Lower is better |
PARP1 Activity | DNA repair enzyme that consumes NAD+ | Balance needed |
Inflammatory Markers (hsCRP, IL-6) | Increased inflammation accelerates NAD+ depletion | hsCRP <1 mg/L |
Advanced Strategies for Your Weekly Schedule
Once you have a baseline, you can look into more advanced strategies. Think of these as ways to fine-tune your protocol for even better results. Always discuss these with your doctor before making changes.
Morning Administration
Your body has a natural clock called circadian rhythm. Your NAD+ levels naturally peak in the morning. Some research suggests that administering your NAD+ dose between 8-10 a.m. can enhance its effects by aligning with your body’s innate cycle. This helps cells use NAD+ more efficiently.
Pulsed Dosing
Instead of taking the same dose every day, pulsed dosing involves a more varied schedule. For example, you might take a higher dose for three days in a row, followed by four days off. This approach may help prevent your body from adapting, keeping your cells sensitive and responsive to NAD+ over the long term.
Ascending Doses
Jumping straight to a high dose can sometimes cause side effects like flushing or nausea. An ascending dose protocol avoids this. You start low (maybe 25-50mg) and slowly increase the dose over several weeks. This gives your body time to adjust and often leads to better long-term tolerance and results.
Instead of beginning with a high dose that might cause side effects like nausea, your protocol will likely start with a smaller amount, maybe 50mg a couple of times a week. This gives your body a chance to adapt beautifully. Then, you’ll gradually increase your dose over a few weeks.
It’s a fantastic way to get all the benefits without the discomfort. And the results speak for themselves – studies on NAD+ precursors show that this kind of approach can lead to significant improvements in metabolic markers, like fasting glucose, in just 10 to 12 weeks.
Combining with Other Compounds
NAD+ doesn’t work in a vacuum. You can enhance its effects by pairing it with other compounds.
- Sirtuin Activators – Compounds like resveratrol can help sirtuins use NAD+ more efficiently.
- Methylation Support – Vitamins like B12 and folate help your body recycle components of the NAD+ molecule.
- Oral Precursors – Some people choose to cycle between injectable NAD+ and oral precursors like NMN or NR. While research typically uses NR doses from 100mg to 1000mg daily, studies show that 250-900mg of NMN can also significantly boost blood NAD+ levels. This hybrid approach can reduce injection frequency while maintaining support.
One of the most exciting benefits of our injectable NAD+ is how it can supercharge your metabolism at a cellular level. To get the most out of every dose, you can use advanced strategies like metabolic cycling. This involves strategically varying your dosage to enhance how your cells respond to the NAD+ you’re providing.
When you’re considering these kinds of advanced protocols, it’s important to understand exactly how NAD+ for energy enhancement and metabolic support is like fuel for your body.
Our 1000mg vial of injectable NAD+ gives you the foundation for your personalized wellness journey.
How to Administer and Monitor Your NAD+
Okay, so now you’ve got a plan. Now for the practical part. Proper administration and careful monitoring are what turn a good plan into a great one.
Administration: Subcutaneous vs. Intramuscular
You’ll typically administer your NAD+ injection dosage in one of two ways:
- Subcutaneous (SubQ) – This is an injection into the fatty tissue just under the skin, using a very small needle. It allows for a slower, more gradual release of NAD+. This is often the preferred method as it minimizes side effects like flushing.
- Intramuscular (IM) – This is an injection directly into the muscle. It offers faster absorption for those seeking more immediate effects.
When deciding, it’s helpful to compare all your options. Our guide on NAD+ injections and IV therapy can help you understand the differences.
While SubQ and IM are common for at-home use, they’re part of a bigger picture. This table breaks down the key differences between the main administration routes –
Administration Route | Typical Dose Range | Onset Time | Duration | Best For |
Intravenous (IV) | 500-1500mg | 1-5 minutes | 2-4 hours | Acute needs, rapid effects |
Intramuscular (IM) | 100-300mg | 15-30 minutes | 4-6 hours | Balance of speed and duration |
Subcutaneous (SubQ) | 50-200mg | 30-60 minutes | 6-8 hours | Gradual release, fewer side effects |
Oral (NAD+ precursors) | 250-1000mg | 1-3 hours | 8-12 hours | Convenience, maintenance |
Sublingual/Nasal | 100-300mg | 10-20 minutes | 3-5 hours | Non-injectable alternative |
A pro tip for comfort – Diluting your dose with sterile saline and administering it slowly over 5-10 minutes can make a world of difference. This is especially true with higher doses.
Monitoring - Become Your Own Health Detective
The best way to know if your protocol is working is to pay attention.
- Biomarker Tracking – We recommend baseline testing before you start and re-testing after 8–12 weeks. This gives us objective data on how your body is responding.
- Therapeutic Journaling – This is your secret weapon. Keep a simple daily journal. On a scale of 1–10, track your:
- Energy levels
- Mental clarity and focus
- Sleep quality
- Mood and stress levels
Note these on both injection days and off days. Over a few weeks, patterns will emerge. This information is invaluable for helping your doctor fine-tune your weekly plan.
A quick spritz is all it takes – our NAD+ nasal spray is a convenient, needle-free way to get your daily NAD+ dose.
Beyond the Injection: Complementary NAD+ Methods
While injectable NAD+ is the gold standard for bioavailability, other innovative methods can complement your weekly protocol.
Topical NAD+ Creams
A fantastic strategy for whole-body wellness is to pair your NAD+ injections with a targeted topical treatment. While your injections work from the inside out, you can give your skin some extra love from the outside in.
One of the best ways to do this is with our powerful NAD+ Face Cream. Using it on non-injection days helps support skin repair and revitalization at a cellular level, tackling everything from fine lines to sun damage. This works especially great if you travel often or just want to enhance your skin’s health.
For those interested in how topical products can fit into a complete wellness plan, our general NAD+ skincare guide provides a great overview of the science.
NAD+ Nasal Sprays
For those who prefer a needle-free approach or want to maintain their NAD+ levels between injections, our nasal spray is a fantastic option. It’s incredibly convenient and designed for fast absorption, delivering benefits that support cognitive function like mental clarity and focus.
Many of our clients use it as a “bridge” on their off-days from injections to keep their energy and focus stable all week long.
Long-Term Success - Keeping the Benefits Going
NAD+ therapy isn’t a one-and-done fix. It’s a long-term strategy for sustained vitality. To keep the benefits coming, it’s smart to think in monthly and yearly cycles.
Quarterly "Resets"
Some evidence suggests that after about 12 weeks of consistent dosing, a short “reset” period can be beneficial. This might involve taking a two-week break or significantly reducing your dose. This simple step-down can help resensitize your cells, making your regular protocol even more effective when you resume.
Economic Optimization
We want your NAD+ journey to be an easy and valuable part of your life. A great way to do that is by getting the most out of every vial.
We offer a high-quality, 1000mg vial of injectable NAD+. This generous size gives you plenty to work with for weeks at a time, making it a great value whether your personal plan calls for smaller or larger doses.
The key to making that value last is proper storage. Simply keeping your vial in the fridge and using a clean, sterile technique protects its potency. That way, you know you’re getting the full benefit from every single drop.
Final Thoughts: Your Personalized Journey with Enovone
Whew, that was a lot of information! But the main takeaway is simple here – NAD+ supplementation is a powerful tool, but its success depends entirely on personalization. The era of one-size-fits-all health is over. You’re in the driver’s seat.
By understanding the principles in this guide – from half-life to circadian rhythms – you’ve got the power to have a more informed conversation with your healthcare provider. You can build a truly customized NAD+ dosage per week that works for your body, your goals, and your life. If you’re curious to see the products that can help you get started, feel free to explore all of our NAD+ treatments and more.
This is what we do at Enovone. We don’t do guesswork. We combine the latest science with a deep understanding of your unique health profile. Our team of board-certified physicians is here to guide you every step of the way.
Ready to boost your energy and restore vitality?
Your journey to optimal energy and cellular health starts here. It all begins with our short 5-minute online assessment. Your answers will help us see if our approach is the right fit for your goals. If it is, we’ll connect you with one of our board-certified doctors for a one-on-one consultation – all from the comfort of your home.
It’s time to feel your absolute best.
