Our busy lives make it challenging to jump between tasks effortlessly. It takes a lot of energy and usually leaves us feeling tired and over-stimulated by midday. Fatigue has become so common and most people aren’t aware of how to combat it. Another thing potentially holding us back is anxiety. Because we’re so engaged all day long and the tasks don’t seem to end, the amount of people suffering from anxiety has shot up. Studies have shown that around 301 million people worldwide were affected by anxiety disorders in 2024. That’s a staggering amount of people, and equates to 4.05% of the world’s population.
Are you really surprised that such a large amount of the population is tired, anxious, or both? We’re most definitely not.
If these stats are hitting home, don’t worry – we’re not just going to point out the obvious, we’ve got a solution. NAD+ IV therapy – if you haven’t heard of it yet, is a groundbreaking treatment that could be the answer to sluggishness. Let’s jump into the ‘how’ and make the case for NAD+. We’ll also talk about why IV therapy isn’t the most efficient form of NAD+ therapy and what alternative may work better for you. Let’s get started!
Table of Contents
TL;DR
- NAD is a crucial molecule that helps your cells produce energy and stay healthy. It can be a quality treatment for fatigue, weight management, and anxiety.
- NAD+ IV therapy delivers this molecule directly into your bloodstream for faster and more noticeable effects.
- While promising, the therapy requires professional administration and isn’t as simple as taking a vitamin.
- NAD+ IV is expensive and not widely available, limiting access for many people. In that case, an injectable form is a better choice.
- Implementing NAD+ IV therapy safely involves trained staff, proper facilities, and monitoring.
- People with certain health conditions or those who are pregnant should be cautious and consult a doctor before trying NAD+ IV.
- Enovone provides a tailored and personalized NAD+ treatment plan that skips the IV drip but matches the outcome.
The Biochemical Revolution Behind NAD+
First, let’s talk about what NAD actually is. Its full name is Nicotinamide Adenine Dinucleotide, and it’s a coenzyme that is already in your body naturally. It’s responsible for countless metabolic processes, and plays a big part in how you feel, too.
One of its main functions is as an electron carrier during cellular respiration, helping convert nutrients into energy. It sounds complicated, but ultimately, it helps your body do what it needs to do more efficiently.
NAD exists in two forms; oxidized (NAD+) and reduced (NADH). It’s important to have a good balance of both of these forms as it affects how efficiently cells produce energy. But there’s more: NAD also supports things like DNA repair, gene expression regulation, and responses to cellular stress.
There are many situations when a person may not get enough NAD+ naturally, and that’s where NAD treatment through IV or injections comes in useful.
The Cellular Energy Crisis
It’s completely normal for your natural NAD+ levels to decline over time with age. Scientists have a name for this – a cellular energy crisis. It sounds far worse than it actually is, but by middle age, it’s likely that you’ve lost around half of your NAD levels. Of course, that’s when you’re more likely to start noticing issues, particularly lack of energy, brain fog, and muscle weakness.
Mitochondrial Function and NAD+
To put it simply, mitochondria make energy for your cells to function. They heavily depend on NAD to generate ATP, also known as adenosine triphosphate. This is the energy currency your cells love. When your NAD+ levels fall, the efficiency of your mitochondria goes in the same direction, resulting in lower energy production.
You notice this in how you feel, but you might simply attribute it to “getting older,” rather than seeing it as something you can address and improve with NAD IV treatment or injections.
Sirtuins: The Longevity Genes
Another part of the puzzle is sirtuins, a family of proteins that are all about longevity, activated by NAD+. These regulate cellular processes such as DNA repair, metabolic function, and inflammatory responses.
When NAD+ is low, sirtuins can’t do their job well, leading to lack of energy and signs of aging. In fact, NAD for energy optimization is one of our best-sellers, which says a lot about this biological relationship.
Beyond Anti-Aging: Therapeutic Applications
Of course, health is wealth, and harnessing the power of IV NAD goes far beyond anti-aging. There are many signs that NAD therapy could help improve quality of life and affect the progression of certain diseases. In fact, studies have shown that NAD therapy could slow down the progression of Alzheimer’s Disease.
This is just one example, and the table below gives a few more:
Therapeutic Application | Potential Mechanism | Evidence Strength |
Neurodegenerative Protection | Enhances mitochondrial function in neurons, reduces toxic protein accumulation | Moderate (multiple animal studies, limited human trials) |
Addiction Recovery | Restores brain chemistry altered by substance abuse, reduces withdrawal symptoms | Preliminary (case reports, limited controlled studies) |
Metabolic Syndrome | Improves insulin sensitivity, enhances mitochondrial biogenesis, increases fat oxidation | Moderate (consistent animal data, emerging human trials) |
Cognitive Enhancement | Supports neuronal energy production, enhances synaptic plasticity | Preliminary (animal studies, anecdotal human reports) |
Cardiovascular Protection | Improves endothelial function, reduces oxidative stress, enhances cardiac energetics | Emerging (preclinical data, limited human biomarker studies) |
The Technical Reality of NAD+ IV Administration
NAD treatments take many forms, and the IV version allows for fast absorption into the bloodstream.
While NAD IV therapy is a very effective and positive treatment, it doesn’t come without a few drawbacks. Most of these are logistical rather than anything else, but it’s still important to weigh the pros and cons. Of course, the alternative is NAD+ injections, which gives the same effects, they’re just administered slightly differently.
Yet, whichever way you take NAD therapy, be it IV infusion or via injection, there are some potential side effects to be aware of. It’s more a case of knowledge is power than anything to be concerned about. That way, you can spot any reactions and know whether they’re common effects or something else.
For extra peace of mind, remember that all our products are FDA approved or compounded medications prepared by reputable pharmacies. Our treatment plans are also tailored specifically to your needs and carefully monitored.
The Infusion Experience Decoded
We’ll get to those potential side effects shortly, but first, let’s talk about the process of having NAD infusion. This process is a little different to regular vitamin infusions, and it’s a good idea to know what to expect before you make a decision on IV versus injections.
When you opt for NAD IV therapy, this is done in a clinic or healthcare setting, overseen by a healthcare professional. The payoff here is time and travel – with injections, you can do these at home by yourself.
The NAD+ goes straight into your bloodstream via an IV catheter in your arm. Each IV bag usually contains between 250-1000 mg of NAD+ mixed in saline, and it flows into your body over a period of time. This can be anywhere between 1.5 to 4 hours. It’s a time-consuming process right off the bat, and the actual time spent depends on the dose.
The Flush Phenomenon
One of the most common experiences people have with IV NAD therapy is called “the flush.” This is a warm sensation, sometimes felt as pressure, or potentially a little discomfort in the face, chest, or abdomen. This reaction is generally normal and harmless, and it happens because the NAD+ temporarily sticks to specific receptors in the body that trigger these feelings. If it’s uncomfortable for you, tell your practitioner and they may be able to adjust the infusion rate.
There are a few other common side effects, and you can explore these in the table below:
Common NAD+ Infusion Side Effects | Frequency | Management Strategies |
Facial/chest flushing | Very Common (>80%) | Slow infusion rate, cold compress |
Abdominal discomfort | Common (40-60%) | Slow infusion rate, small meal beforehand |
Headache | Common (30-50%) | Proper hydration, slow infusion rate |
Nausea | Moderate (20-40%) | Anti-nausea medication, slow infusion rate |
Fatigue during infusion | Moderate (20-30%) | Rest during treatment, proper hydration |
Temporary blood pressure changes | Uncommon (5-15%) | Regular monitoring, adjust rate as needed |
Vein irritation | Uncommon (5-10%) | Proper dilution, skilled IV placement |
Dizziness | Rare (<5%) | Reclined position, slow infusion rate |
Allergic reaction | Very Rare (<1%) | Immediate medical attention |
Economic and Accessibility Considerations
There are many NAD treatments on the market, so it’s important to consider whether NAD IV is the best route, or whether something else may suit you better. Every person’s situation is different, so it’s vital to see this through your own eyes and not anyone else’s. However, there’s one particular aspect of NAD IV therapy that can create a huge barrier, and that’s the cost.
NAD infusion is generally more expensive than regular NAD+ injections because of the way it is administered, the time it takes, and the fact it requires medical oversight. This is something that regular at-home injections simply don’t need.
The True Cost Analysis
To decide whether the IV route is best for you, it’s important to consider the true cost with everything included. In many cases, the price goes beyond what you originally advertised, and you don’t want to end up signing up for something that’s going to cost you far more in the end.
Price Variation Factors
On average, NAD IV therapy costs $200 to $1,500 per session. However, the actual price varies by location, facility and provider’s credentials. Generally, urban clinics and spas charge more because of their location, but you might find a more competitive price in a medical practice if you shop around.
Hidden Costs of Treatment
Hidden costs can drastically increase the baseline price you’re quoted, so it’s vital to dig a little deeper and make sure you have the full picture. Beyond the initial consultation, there may be recommended blood work, and travel time and lost productivity due to the time the treatment takes.
It’s fair to say that IV NAD treatments are some of the most expensive around, so it’s important to know what you’re signing up for financially. If the price and time factor is too much for you, injections are a cheaper and more time-effective solution.
Insurance Coverage Reality
There’s also insurance to think about. Many plans classify NAD treatments as experimental or wellness-focused, which can lead to limited insurance coverage, or in some cases, no coverage at all.
We’ve already talked about the fact that NAD IV therapy is one of the most expensive options, and it can, in some cases, go into thousands of dollars for a full course. If your insurance cannot cover even part of this, the financial burden may simply be too much. In that case, starting on NAD+ injections might be most cost-effective for you.
Alternative Delivery Systems
Choosing the best NAD treatment method is a personal process, and it’s a good idea to learn about the alternatives as part of that. The other two options include NAD+ nasal spray and subcutaneous NAD+ injections, which we’ve touched up on a few times already.
Subcutaneous NAD+ Injections
NAD therapy via injection is a time-efficient, low-cost way to boost longevity and well-being.
Subcutaneous NAD+ injections are given under the skin at home, and you can administer them yourself. The obvious plus points here are lower cost and time consumption, but it’s important to remember that they do deliver smaller amounts of NAD compared to IV infusion.
Despite that, learning to give yourself these injections is fast and easy once you get the hang of it. Our injection vials contain up to 20 doses within one pack, which will cover you for one month.
Nasal Options
Not everyone is a fan of needles, and in that case, intranasal and sublingual products are a good alternative. Our nasal spray comes with a month’s supply all within a 15mL bottle. This is then used twice daily, with one spray in each nostril.
You might wonder how this works, but the inside of your nose is full of veins, rich in blood supply. When the product is sprayed into your nose, it is absorbed into your bloodstream and acts fast, all without a needle.
Starting on NAD+ nasal spray is fast, easy, and a good alternative to IV NAD.
Practical Implementation Strategies
Once you’ve done your homework and researched all the different NAD treatment options, it’s time to prepare. Regardless of whether you opt for IV NAD, subcutaneous injections, or nasal spray, there are some steps to follow to ensure safety and boost your results.
Preparation Optimization
Preparation really is key and it’s important to follow all steps. After all, no matter what type of NAD treatment you go for, it still costs money and you want the best outcome. One of the most important preparation steps is hydration. Being properly hydrated before and during treatment can improve efficiency and improve overall health.
For NAD IV therapy in particular, proper hydration can ensure better circulation, delivering nutrients where they need to go and helping the NAD flow better. It can also give you better electrolyte balance, which can help reduce side effects, such as headaches and nausea.
So, how much should you drink? There are no solid rules, but the general recommendation for IV hydration is 1-2 liters of fluids 12 hours before the treatment. If you can add some electrolytes to those fluids, even better.
The checklist below gives you all the information you need to prepare for your NAD infusion.
NAD+ IV Therapy Preparation Checklist:
- [ ] Hydrate with 1-2 liters of electrolyte-containing fluids in the 12 hours before treatment
- [ ] Avoid alcohol for 24 hours before treatment
- [ ] Consume a light, balanced meal 1-2 hours before appointment
- [ ] Avoid caffeine on the morning of treatment
- [ ] Wear comfortable clothing with easy access to arms for IV placement
- [ ] Bring entertainment (books, tablet, headphones) for the extended session
- [ ] Arrange transportation home if this is your first session
- [ ] Inform provider of all medications and supplements taken in the past week
- [ ] Plan for 2-4 hours of seated time for the complete infusion
- [ ] Bring a light snack in case of hunger during the extended session
Post-Treatment Maximization
You can also take actions after the IV NAD is over to help boost effectiveness. At this point, hydration is still important as it helps to flush out toxins and supports cellular function in general. Yet, after the NAD infusion, it’s also vital to rest. Some people feel tired after an infusion or experience headaches or nausea. Simply resting and taking your time can help you feel better quickly.
It’s also best to avoid alcohol and caffeine for at least 24 hours after the treatment, eat light, and listen to your body. If you notice anything unusual, such as prolonged nausea, dizziness, or signs of an allergic reaction, reach out to your healthcare provider. Of course, you should also follow any instructions they give you once the treatment is complete.
Exercise Timing Windows
There is some evidence to suggest that moderate exercise within 24 hours may boost cellular uptake and utilization.
You certainly shouldn’t overdo the exercise once you’ve had an IV infusion, but light to moderate activity may be beneficial.
Nutritional Synergies
What you eat is also important after your NAD+ therapy. For instance, anti-inflammatory and polyphenol-rich foods can enhance NAD+ pathways. However, inflammatory foods can work in reverse.
To simplify this, focus on foods like colorful berries, omega-3 rich foods, and green vegetables. Also keep processed foods and refined carbohydrates to a minimum.
The checklist below pulls everything together in one place:
Post-NAD+ Therapy Nutrition Plan:
- First 24 Hours:
- Emphasize polyphenol-rich foods (berries, dark chocolate, green tea)
- Include omega-3 sources (wild salmon, walnuts, flaxseed)
- Maintain moderate protein intake (1.2-1.6g/kg body weight)
- Minimize refined carbohydrates and processed foods
- Stay well-hydrated with electrolyte-containing fluids
- Days 2-7:
- Continue anti-inflammatory food focus
- Include NAD+ precursor-rich foods (mushrooms, fish, green vegetables)
- Consider intermittent fasting if appropriate for your health status
- Limit alcohol consumption which depletes NAD+
- Maintain adequate B-vitamin intake through whole foods or supplements
- Ongoing Maintenance:
- Regular consumption of colorful plant foods rich in polyphenols
- Periodic 12-16 hour fasting periods if medically appropriate
- Moderate protein intake from varied sources
- Limited processed food consumption
- Adequate hydration throughout the day
Special Population Considerations
There is no ‘one size fits all’ answer to anything health-related, and the same goes for NAD IV therapy. However, there are some demographic groups that might experience specific benefits or risks in particular, along with some special considerations. In this section, we’ll take a deeper look at these, helping you choose the best treatment for your needs.
Athletic Performance Applications
Athletes can benefit from increased recovery and energy thanks to NAD treatments.
If you’re a competitive athlete, you’re part of a group that is starting to explore NAD+ therapy with greater interest. Of course, there are specific considerations here that go beyond general wellness or longevity. Let’s explore some of the most interesting ones.
Recovery Acceleration Potential
If you regularly take part in high-volume or high-intensity training, NAD treatments could be useful for you. Studies have shown that NAD+ therapy may speed up recovery because they support mitochondrial regeneration, while also improving endurance and energy efficiency.
Anti-Doping Compliance Issues
Of course, athletes are very concerned with ensuring they stay within anti-doping regulations, so there’s a conversation to be had about this and NAD’s status.
Currently, NAD+ doesn’t appear on the World Anti-Doping Agency list. However, there are some related compounds that may fall under a different category and could be classified within the S4 or S6 group. For that reason, it’s important to check with your National Anti-Doping Organization for peace of mind.
Neurocognitive Condition Implications
People who have neurocognitive conditions or worries related to them often look toward NAD therapy. We talked earlier about how this type of therapy has some use in Alzheimer’s cases, and it can also boost general brain health. Yet, there are other potential uses.
Following a traumatic brain injury, cerebral NAD+ levels are reduced. However, there is plenty of evidence to suggest that replacing NAD following a concussion can support neuronal energy production, which is very important during recovery.
As far as cognitive decline goes in general, new research on NAD+ before and after effects shows promising results, particularly in memory function and processing speed improvements.
Autoimmune Complexity Factors
We can also talk about autoimmune conditions. People who have these issues may also benefit from NAD+ therapy because it helps support cell health and reduces inflammation – the very thing that worsens these conditions.
With increased NAD+ the body is able to manage stress better and repair damaged cells. This can ease symptoms and boost overall immune function.
Medication Interaction Awareness
Despite its benefits, it’s important to think about medication interactions. If you do have an autoimmune condition and you’re considering NAD treatments, first think about the medications you’re currently on.
Some drugs commonly prescribed for some autoimmune conditions can change how the body uses NAD. Of particular note here is Methotrexate, which is often used to treat rheumatoid arthritis. This changes how the body processes folate which affects NAD activity.
Again, every person’s situation is different, so it’s important to discuss potential drug interactions with your healthcare professionals. If you’re attending a clinic or spa for NAD IV therapy, or you’re considering contacting us for nasal sprays or NAD injections, remember to disclose your medications as a matter of urgency. Safety always comes first, after all.
Final Thoughts: Making Informed Decisions About NAD+ IV Therapy
We’ve reached the end of our dive into the world of IV NAD, and you now know everything you need to make an informed decision. It’s clear that NAD+ therapy has serious promise and excellent benefits for many problems, including fatigue, weight management, and anxiety. There’s also plus points for certain specialities, including athletes, people with cognitive problems, and those with autoimmune issues.
The future really does seem quite bright.
However, IV infusions come with downsides, mainly cost and time commitment. In that case, looking at alternatives is a good option, and our at-home injections are the perfect answer.
At Enovone, we believe everyone should have a chance to feel their best. That’s why we’ve developed our unique telemedicine service that’s completely focused on giving you the longevity, energy, and focus you need. We work with you to create a personalized medication plan, tailored to the areas you want to focus on. Our products are FDA-approved, cost-effective, and easy to use.
Your first step is taking a short online assessment, and from your answers we’ll assess whether you’re eligible for our services. We’ll then connect you with one of our board-certified doctors for a consultation, helping you get started on the road to feeling better.
We serve all states apart from LA and MS, so if you’re ready to get started, it just takes one small action – reach out to us today!
